(2Z)-2-(2-AMINOTHIAZOL-4-YL)-N-(FORMYLMETHYL)-2-(METHOXYIMINO)ACETAMIDE
| 中文名称 | (2Z)-2-(2-AMINOTHIAZOL-4-YL)-N-(FORMYLMETHYL)-2-(METHOXYIMINO)ACETAMIDE |
|---|---|
| 中文同义词 | 阿托伐他汀环氧四氢呋喃类似物;阿托伐他汀环氧四氢呋喃杂质;阿托伐他汀钙环氧四氢呋喃类似物;阿托伐他汀杂质L;阿托伐他汀环氧四氢呋喃类似物(USP);阿托伐他汀四氢呋喃类似物;阿托伐他汀环氧四氢呋喃类似物对照品;阿托伐他汀四氢呋喃环氧杂质 |
| 英文名称 | Atorvastatin Epoxy Tetrahydrofuran IMpurity |
| 英文同义词 | Atorvastatin Epoxy Tetrahydrofuran IMpurity;4-(4-fluorophenyl)-2,4-dihydroxy-N,5-diphenyl-2-propan-2-yl-3,6-dioxabicyclo[3.1.0]hexane-1-carboxamide;Atorvastatin Epoxy Tetrahydrofuraran analog;4-(4-fluorophenyl)-2,4-dihydroxy;Atorvastatin impurity 28/Atorvastatin Epoxy Tetrahydrofuran Impurity/4-(4-Fluorophenyl)-2,4-dihydroxy-2-(1-methylethyl)-N,5-diphenyl-3,6-dioxabicyclo[3.1.0]hexane-1-carboxamide;Atorvastatin epoxy tetrahydrofuran;4-(4-Fluorophenyl)-2,4-dihydroxy-2-(1-Methylethyl)-N,5-diphenyl-3,6-dioxabicyclo[3.1.0]hexane-1-carboxaMide;Atorvastatin Photo Degradation Product |
| CAS号 | 873950-19-7 |
| 分子式 | C26H24FNO5 |
| 分子量 | 449.47 |
| EINECS号 | |
| 相关类别 | 杂质对照品;对照品-杂质对照品;杂质;标准品;阿托光照降解杂质;049-阿托伐他汀钙;Amines;Aromatics;Chiral Reagents;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 873950-19-7.mol |
| 结构式 |  |
(2Z)-2-(2-AMINOTHIAZOL-4-YL)-N-(FORMYLMETHYL)-2-(METHOXYIMINO)ACETAMIDE 性质
| 熔点 | >163°C (dec.) |
|---|---|
| 沸点 | 661.1±55.0 °C(Predicted) |
| 密度 | 1.435±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C Freezer, Under inert atmosphere |
| 溶解度 | 可溶于氯仿（少量）、DMSO |
| 酸度系数(pKa) | 10.43±0.70(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| 主要应用 | pharmaceutical |
Atorvastatin Epoxy Tetrahydrofuran Impurity 是阿托伐他汀 (Atorvastatin；HY-B0589) 氧化降解产物的一种杂质。Atorvastatin 是一种具有口服活性的 HMG-CoA 还原酶抑制剂，具有有效降低血脂的能力。
Atorvastatin treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |