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| | 4-(TrifluoroMethoxy)benzeneacetic acid ethyl ester Basic information |
| Product Name: | 4-(TrifluoroMethoxy)benzeneacetic acid ethyl ester | | Synonyms: | 4-(TrifluoroMethoxy)benzeneacetic acid ethyl ester;(4-Trifluoromethoxy-phenyl)-acetic acid ethyl ester;ethyl 2-(4-(trifluoromethoxy)phenyl)acetate;Ethyl 2-(4-(trifluoromethoxy);Benzeneacetic acid, 4-(trifluoromethoxy)-, ethyl ester | | CAS: | 1206550-93-7 | | MF: | C11H11F3O3 | | MW: | 248.2 | | EINECS: | | | Product Categories: | | | Mol File: | 1206550-93-7.mol |  |
| | 4-(TrifluoroMethoxy)benzeneacetic acid ethyl ester Chemical Properties |
| Boiling point | 240.6±35.0 °C(Predicted) | | density | 1.246±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | Appearance | Colorless to off-white Solid-Liquid Mixture |
| | 4-(TrifluoroMethoxy)benzeneacetic acid ethyl ester Usage And Synthesis |
| Chemical Properties | light yellow liquid | | Synthesis | a) Concentrated sulfuric acid (0.484 mL, 9.08 mmol) was added slowly and dropwise to a solution of 2-(4-(trifluoromethoxy)phenyl)acetic acid (2.0 g, 9.08 mmol) in anhydrous ethanol (20 mL), which was subsequently heated to reflux and held for 5 hours. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure to remove the solvent and then diluted with ethyl acetate (100 mL). The diluted solution was washed sequentially with saturated sodium bicarbonate solution and saturated brine to remove acidic impurities and inorganic salts. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated again under reduced pressure to give the crude product. The crude product was purified by column chromatography (eluent: ethyl acetate/hexane, gradient elution, 0/100 to 20/80) to finally obtain ethyl 2-(4-(trifluoromethoxy)phenyl)acetate (2.06 g, 91% yield) as a yellow oil. | | References | [1] Patent: US2011/136833, 2011, A1. Location in patent: Page/Page column 36 |
| | 4-(TrifluoroMethoxy)benzeneacetic acid ethyl ester Preparation Products And Raw materials |
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