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| | ()-AS 115 Basic information |
| Product Name: | ()-AS 115 | | Synonyms: | ()-AS 115;BTYYXSHZANWPEB-ZWKOTPCHSA-N;Carbamic acid, N-[2-[[(1R,2S)-2-(butoxymethyl)cyclohexyl]methoxy]ethyl]-, 2-fluorophenyl ester, rel-;(–)-AS 115, CAS 926657-43-4 | | CAS: | 926657-43-4 | | MF: | C21H32FNO4 | | MW: | 381.48 | | EINECS: | | | Product Categories: | | | Mol File: | 926657-43-4.mol |  |
| | ()-AS 115 Chemical Properties |
| Boiling point | 460.272±43.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.073±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | solubility | DMF: 12 mg/ml; DMSO: 12 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml | | pka | 10.844±0.46(predicted) |
| | ()-AS 115 Usage And Synthesis |
| Description | KIAA1363 is a 2-acetyl monoacylglyceryl ether (MAGE) hydrolase that is upregulated in aggressive cancers from various tissues.1 The enzyme catalyzes the hydrolysis of the 2-acetyl MAGE to MAGE and serves as a central enzyme in the PAF and LPA signaling network.2 AS 115 is a potent and selective inactivator of KIAA1363, displaying an IC50 value of 150 nM when tested as a racemic mixture in the invasive ovarian cancer cell line SKOV3.2 Treatment of SKOV3 cells with 10 μM AS-115 for 4 hours significantly reduced the formation of MAGE, alkyl-lysophosphatidylcholine, and alkyl-lysophosphatidic acid. The activity of the individual enantiomers of AS 115, i.e. (+)-AS 115 and ()-AS 115, has not been determined. | | Uses | AS115 is a potent and selective KIAA1363 inactivator with IC50 value of 150 nM. KIAA1363 is a 2-acetyl monoacylglycerol ether (MAGE) hydrolase that is upregulated in aggressive cancers of various tissues[1][2]. | | References | 1. Jessani, N., Liu, Y., Humphrey, M., et al. Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness Proc. Natl. Acad. Sci. USA 99(16),10335-10340(2002).
2. Chiang, K.P., Niessen, S., Saghatelian, A., et al. An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling Chem. Biol. 13(10),1041-1050(2006). |
| | ()-AS 115 Preparation Products And Raw materials |
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