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| | TRAF5 Monoclonal Antibody (Clone 55A219) Basic information |
| | TRAF5 Monoclonal Antibody (Clone 55A219) Chemical Properties |
| | TRAF5 Monoclonal Antibody (Clone 55A219) Usage And Synthesis |
| Description | Tumor necrosis factor (TNF)-induced signaling is mediated through association of TNF receptor (TNFR) with adaptor proteins, such as TNF receptor-associated factors (TRAFs). TRAFs form a family of cytoplasmic adapter proteins that mediate signal transduction from many members of the TNF-receptor superfamily (e.g., RANK, CD30, CD40, etc.) and the interleukin-1 receptor. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. Recent molecular cloning studies have led to identification of seven TRAFs (TRAF1-TRAF7). Human TRAF5 is a 557-amino acid protein. TRAF5 is implicated in NF-kB and c-Jun NH(2)-terminal kinase/stress-activated protein kinase activation by members of the TNF receptor superfamily, including CD27, CD30, CD40, and lymphotoxin-β receptor. Targeted disruption of TRAF5 gene causes defects in CD40-CD27 mediated lymphocyte activation. | | References | [1] H NAKANO. Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1999, 96 17: 9803-9808. DOI: 10.1073/pnas.96.17.9803
[2] ZHAODAN CAO. TRAF6 is a signal transducer for interleukin-1[J]. Nature, 1996, 383 6599: 443-446. DOI: 10.1038/383443a0
[3] M ROTHE. A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.[J]. Cell, 1994, 78 4: 681-692. DOI: 10.1016/0092-8674(94)90532-0
[4] GENHONG CHENG. Involvement of CRAF1, a relative of TRAF, in CD40 signaling[J]. Science, 1995, 267 5203. DOI: 10.1126/science.7533327
[5] H NAKANO. TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor.[J]. The Journal of Biological Chemistry, 1996, 271 25: 14661-14664. DOI: 10.1074/jbc.271.25.14661 |
| | TRAF5 Monoclonal Antibody (Clone 55A219) Preparation Products And Raw materials |
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