(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
生物活性体内研究 用途与合成方法 MSDS (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride价格(试剂级) 上下游产品信息
| 中文名称 | (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride |
|---|---|
| 中文同义词 | PF-04859989 盐酸盐;化合物PF-04859989;(S)-3-氨基-1-羟基-3,4-二氢喹啉-2(1H)-酮盐酸;化合物PF-04859989,10 MM DMSO 溶液 |
| 英文名称 | (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride |
| 英文同义词 | (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride;(3S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one;L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride;PF04859989 hydrochloride;PF-04859989 hydrochloride;PF-4859989 hydrochloride;PF 04859989 hydrochloride - L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride;PF-04859989 hydrochloride >=98% (HPLC) |
| CAS号 | 177943-33-8 |
| 分子式 | C9H11ClN2O2 |
| 分子量 | 214.64884 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 177943-33-8.mol |
| 结构式 |  |
(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride 性质
| 储存条件 | room temp |
|---|---|
| 溶解度 | 在水中的溶解度为20mg/mL，澄清 |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 水溶解性 | Water: 22 mg/ml |
| InChI | 1S/C9H10N2O2.ClH/c10-7-5-6-3-1-2-4-8(6)11(13)9(7)12;/h1-4,7,13H,5,10H2;1H/t7-;/m0./s1 |
| InChIKey | WZOBDOKCHIUXAY-FJXQXJEOSA-N |
| SMILES | N[C@H]1CC2=CC=CC=C2N(O)C1=O.Cl |
PF-04859989 hydrochloride 是一种可透过血脑屏障的，不可逆的犬尿氨酸转氨酶 KAT II 抑制剂，对 hKATⅡ 和 rKATⅡ 的 IC50 分别为 23 和 263 nM。PF-04859989 hydrochloride 对 KATⅡ 的选择性高于人 KATⅠ、KATⅢ 和 KATⅣ (IC50 分别为22、11和 >50 μM)。
In vivo pharmacokinetic and efficacy studies in rat show that PF-04859989 is a brain-penetrant, irreversible inhibitor and is capable of reducing brain kynurenic acid by 50% at a dose of 10 mg/kg (sc).
Rats receiving PF-04859989 (5 mg/kg; i.p.) exhibited a significantly lower number of spontaneously active DA neurons pertrack.
| Animal Model: | Male Sprague-Dawley rats |
| Dosage: | 5 mg/kg |
| Administration: | I.p. |
| Result: | Exhibited a significantly lower number of spontaneously active dopamine (DA) neurons pertrack compared to controls. |
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-116451 | PF-04859989 hydrochloride | 177943-33-8 | 1 mg | 300元 |
| 2025/12/22 | HY-116451 | (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride PF-04859989 hydrochloride | 177943-33-8 | 5mg | 600元 |