1H-Indole-2,4-dione, 3-[2,5-dihydro-3-methyl-5-oxo-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-4-yl]-3,5,6,7-tetrahydro-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-

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1H-Indole-2,4-dione, 3-[2,5-dihydro-3-methyl-5-oxo-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-4-yl]-3,5,6,7-tetrahydro-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)- Suppliers list
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1H-Indole-2,4-dione, 3-[2,5-dihydro-3-methyl-5-oxo-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-4-yl]-3,5,6,7-tetrahydro-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)- manufacturers

  • ELOVL6-IN-2
  • ELOVL6-IN-2 pictures
  • $33.00
  • 2026-08-30
  • CAS:1067647-43-1
  • Purity: 99.95%
  • Supply Ability: 10g
1H-Indole-2,4-dione, 3-[2,5-dihydro-3-methyl-5-oxo-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-4-yl]-3,5,6,7-tetrahydro-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)- Basic information
Product Name:1H-Indole-2,4-dione, 3-[2,5-dihydro-3-methyl-5-oxo-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-4-yl]-3,5,6,7-tetrahydro-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-
Synonyms:6,6-Dimethyl-3-(5-methyl-3-oxo-2-(4-(trifluoromethoxy)phenyl)-2,3-dihydro-1H-pyr zol-4-yl)-1-phen;6,6-Dimethyl-3-(5-methyl-3-oxo-2-(4-(trifluoromethoxy)phenyl)-2,3-dihydro-1H-pyrzol-4-yl)-1-ph;6,6-Dimethyl-3-(5-methyl-3-oxo-2-(4-(trifluoromethoxy)phenyl)-2,3-dihydro-1H-pyrzol-4-yl)-1-phenyl-3-(trifluoromethyl)-6,7-dihydro-1H-indole-2,4(3H,5H)-dione;ELOVL6-IN-2;6,6-Dimethyl-3-(5-methyl-3-oxo-2-(4-(trifluoromethoxy)phenyl)-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-6,7-dihydro-1H-indole-2,4(3H,5H)-dione;ELOVL6IN2,ELOVL6 IN 2,plasma,inhibit,selective,ELOVL-6-IN-2,liver,dose-proportionally,Inhibitor,potent,orally;ELOVL6-IN-2, 10 mM in DMSO;1H-Indole-2,4-dione, 3-[2,5-dihydro-3-methyl-5-oxo-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-4-yl]-3,5,6,7-tetrahydro-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-
CAS:1067647-43-1
MF:C28H23F6N3O4
MW:579.49
EINECS:
Product Categories:
Mol File:1067647-43-1.mol
1H-Indole-2,4-dione, 3-[2,5-dihydro-3-methyl-5-oxo-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-4-yl]-3,5,6,7-tetrahydro-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)- Structure
1H-Indole-2,4-dione, 3-[2,5-dihydro-3-methyl-5-oxo-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-4-yl]-3,5,6,7-tetrahydro-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)- Chemical Properties
Boiling point 609.6±65.0 °C(Predicted)
density 1.49±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO : 100 mg/mL (172.57 mM; Need ultrasonic)
pka-1.24±0.70(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
1H-Indole-2,4-dione, 3-[2,5-dihydro-3-methyl-5-oxo-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-4-yl]-3,5,6,7-tetrahydro-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)- Usage And Synthesis
UsesELOVL6-IN-2 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-2 inhibits mouse ELOVL6 activities, with an IC50 value of 34 nM[1].
in vivo

ELOVL6-IN-2 (0.1~1mg/kg; p.o.; 2 hours) potently and dose-proportionally suppresses the elongation index in the liver[1].
ELOVL6-IN-2 (10mg/kg; p.o.; 2 hours) demonstrates highly liver penetrable[1].
ELOVL6-IN-2 (1mg/kg; p.o.; 2~24 hours) exhibits sustained plasma exposure[1].

Animal Model:Male C57BL/6J mice
Dosage:0.1~1mg/kg
Administration:P.o
Result:Potently and dose-proportionally suppressed the elongation index in the liver.
Animal Model:Male C57BL/6J mice
Dosage:10 mg/kg
Administration:P.o
Result:Demonstrated highly liver penetrable.
Animal Model:Male C57BL/6J mice
Dosage:1 mg/kg
Administration:P.o
Result:Exhibited sustained plasma exposure.
References[1] akahashi T, et al. Synthesis and evaluation of a novel indoledione class of long chain fatty acid elongase 6 (ELOVL6) inhibitors. J Med Chem. 2009;52(10):3142-3145. DOI:10.1021/jm900391x
1H-Indole-2,4-dione, 3-[2,5-dihydro-3-methyl-5-oxo-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-4-yl]-3,5,6,7-tetrahydro-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)- Preparation Products And Raw materials
Tag:1H-Indole-2,4-dione, 3-[2,5-dihydro-3-methyl-5-oxo-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-4-yl]-3,5,6,7-tetrahydro-6,6-dimethyl-1-phenyl-3-(trifluoromethyl)-(1067647-43-1) Related Product Information
Morpholine, 2-phenyl-4-[6-[[cis-3-(1H-pyrazol-1-yl)cyclobutyl]oxy]-4-pyrimidinyl]-, (2S)- 6,6-dimethyl-3-(5-methyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-5,7-dihydroindole-2,4-dione Cyclopropanecarboxamide, 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]- Mouse Serum Albumin 8-Azabicyclo[3.2.1]octane-8-carboxamide, 3-(2-pyridinylsulfonyl)-N-[4-(trifluoromethyl)phenyl]-