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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767 |
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Product Name:Sumatriptan-d6 (succinate)
CAS:1397195-80-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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CHINA ISOTOPE CO., LIMITED
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02151600108 13062666369 |
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Product Name:Sumatriptan-d6 Hemisuccinate
CAS:1397195-80-0
Purity:1mg Package:1mg Remarks:RMCS80034-1mg
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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021-65675885 18964387627 |
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customer_service@efebio.com |
| Products Intro: |
Product Name:Sumatriptan-d6 Hemisuccinate
CAS:1397195-80-0
Purity:95% Package:1mg
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TLC Pharmaceutical Standards Ltd.
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18012923235 18012923235 |
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chinasales04@tlcstandards.com.cn |
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Product Name:Sumatriptan-d6 Hemisuccinate
CAS:1397195-80-0
Purity:95%+ HPLC Package:10mg;25mg;50mg;100mg
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Cayman Chemical Company
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800-364-9897 |
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sales@caymanchem.com |
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Product Name:Sumatriptan-d6 (succinate)
CAS:1397195-80-0
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| | SUMATRIPTAN-D6 HEMISUCCINATE Basic information |
| | SUMATRIPTAN-D6 HEMISUCCINATE Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: soluble | | form | A solid |
| | SUMATRIPTAN-D6 HEMISUCCINATE Usage And Synthesis |
| Uses | Sumatriptan-d6 (hemisuccinate) is the deuterium labeled Sumatriptan hemisuccinate[1]. | | Biological Activity | Sumatriptan-d6 is intended for use as an internal standard for the quantification of sumatriptan by GC- or LC-MS. Sumatriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 9.3 and 7.3 nM, respectively).1 It also binds to the 5-HT1F receptor (IC50 = 17.8 nM). It induces vasoconstriction in isolated human middle meningeal arteries (EC50 = 89.9 nM), an effect that can be reduced by the 5-HT1B/1D receptor antagonists GR125743 and GR127935 . Sumatriptan reduces acute, but not chronic, mechanical hyperalgesia in a mouse model of pain induced by nitroglycerin, which is a known migraine trigger in humans.2 Formulations containing sumatriptan have been used in the treatment of migraine headache. | | References | 1.Razzaque, Z., Heald, M.A., Pickard, J.D., et al.Vasoconstriction in human isolated middle meningeal arteries: Determining the contribution of 5-HT1B- and 5-HT1F-receptor activationBr. J. Pharmacol.47(1)75-82(1999)
2.Pradhan, A., Smith, M.L., McGuire, B., et al.Characterization of a novel model of chronic migrainePain155(2)269-274(2014) |
| | SUMATRIPTAN-D6 HEMISUCCINATE Preparation Products And Raw materials |
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