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| | SUMATRIPTAN-D6 HEMISUCCINATE Basic information |
| | SUMATRIPTAN-D6 HEMISUCCINATE Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: soluble | | form | A solid |
| | SUMATRIPTAN-D6 HEMISUCCINATE Usage And Synthesis |
| Uses | Sumatriptan-d6 (hemisuccinate) is the deuterium labeled Sumatriptan hemisuccinate[1]. | | Biological Activity | Sumatriptan-d6 is intended for use as an internal standard for the quantification of sumatriptan by GC- or LC-MS. Sumatriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 9.3 and 7.3 nM, respectively).1 It also binds to the 5-HT1F receptor (IC50 = 17.8 nM). It induces vasoconstriction in isolated human middle meningeal arteries (EC50 = 89.9 nM), an effect that can be reduced by the 5-HT1B/1D receptor antagonists GR125743 and GR127935 . Sumatriptan reduces acute, but not chronic, mechanical hyperalgesia in a mouse model of pain induced by nitroglycerin, which is a known migraine trigger in humans.2 Formulations containing sumatriptan have been used in the treatment of migraine headache. | | References | 1.Razzaque, Z., Heald, M.A., Pickard, J.D., et al.Vasoconstriction in human isolated middle meningeal arteries: Determining the contribution of 5-HT1B- and 5-HT1F-receptor activationBr. J. Pharmacol.47(1)75-82(1999)
2.Pradhan, A., Smith, M.L., McGuire, B., et al.Characterization of a novel model of chronic migrainePain155(2)269-274(2014) |
| | SUMATRIPTAN-D6 HEMISUCCINATE Preparation Products And Raw materials |
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