ethyl 5-hydroxy-2-Methylnicotinate manufacturers
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| | ethyl 5-hydroxy-2-Methylnicotinate Basic information |
| Product Name: | ethyl 5-hydroxy-2-Methylnicotinate | | Synonyms: | ethyl 5-hydroxy-2-Methylnicotinate;5-hydroxy-2-methyl-nicotinic acid ethyl ester;3-Pyridinecarboxylic acid, 5-hydroxy-2-methyl-, ethyl ester;ethyl 5-hydroxy-2-methylpyridine-3-carboxylate | | CAS: | 60390-47-8 | | MF: | C9H11NO3 | | MW: | 181.19 | | EINECS: | | | Product Categories: | | | Mol File: | 60390-47-8.mol |  |
| | ethyl 5-hydroxy-2-Methylnicotinate Chemical Properties |
| Boiling point | 369.6±37.0 °C(Predicted) | | density | 1.193±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | pka | 8.82±0.10(Predicted) | | Appearance | Light yellow to yellow Solid |
| | ethyl 5-hydroxy-2-Methylnicotinate Usage And Synthesis |
| Synthesis | Preparation of compound A24: To a solution of A23 (10.0 g, 44.8 mmol) in methanol (300 mL) was added potassium carbonate (12.4 g, 89.8 mmol). The reaction mixture was stirred for 12 h at room temperature and then quenched by pouring into ice water. The pH was adjusted to 8-9 with 2N hydrochloric acid and subsequently extracted with ethyl acetate (2 x 100mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give compound A24 (8.00 g, 99% yield) as a yellow solid.1H NMR (400 MHz, DMSO-d6) δ: 10.0 (s, 1H), 8.18 (d, J=2.4 Hz, 1H), 7.54 (d, J=2.8 Hz, 1H), 4.32- 4.26 (q, J=3.2Hz, 2H), 2.57 (s, 3H), 1.33-1.29 (t, J=3.2Hz, 3H). | | References | [1] Patent: US2012/238751, 2012, A1. Location in patent: Page/Page column 32
[2] Patent: WO2014/43272, 2014, A1. Location in patent: Paragraph 0430; 0434; 0435 |
| | ethyl 5-hydroxy-2-Methylnicotinate Preparation Products And Raw materials |
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