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Product Name:(±)-Asenapine-13C-d3 hydrochloride
CAS:1261392-55-5
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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Product Name:Asenapine-[13C,d3] hydrochloride
CAS:1261392-55-5
Purity:1mg Package:1mg
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CHINA ISOTOPE CO., LIMITED
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Product Name:Asenapine-13C-d3 HCl
Purity:1mg Package:1mg Remarks:RMCA72007-1mg
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Shanghai Yifei Biotechnology Co. , Ltd.
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| Products Intro: |
Product Name:(±)-Asenapine-13C-d3 (hydrochloride)
CAS:1261392-55-5
Purity:95% Package:1mg
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| | Asenapine-13C-D3 hydrochloride Basic information |
| Product Name: | Asenapine-13C-D3 hydrochloride | | Synonyms: | Asenapine-13C-D3 hydrochloride;[13C,2H3]-Asenapine hydrochloride;(3aR,12bR)-5-Chloro-2-(methyl-13C-d3)-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole hydrochloride;2H3]-Asenapine hydrochloride;(±)-Asenapine-13C-d3 (hydrochloride) | | CAS: | 1261392-55-5 | | MF: | C17H13ClD3NO.ClH | | MW: | 326.24 | | EINECS: | | | Product Categories: | | | Mol File: | 1261392-55-5.mol |  |
| | Asenapine-13C-D3 hydrochloride Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: Soluble,Methanol: Soluble | | form | A solid |
| | Asenapine-13C-D3 hydrochloride Usage And Synthesis |
| Uses | (±)-Asenapine-13C,d3 (hydrochloride) is 13C and deuterium labeled (±)-Asenapine (hydrochloride)[1]. | | Biological Activity | (±)-Asenapine-13C-d3 is intended for use as an internal standard for the quantification of (±)-asenapine by GC- or LC-MS. (±)-Asenapine is an atypical antipsychotic.1,2 It binds to dopamine D1-4, α-adrenergic, and histamine receptors (Kis = 0.42-1.45, 0.32-1.26, and 1-6.17 nM, respectively), as well as the serotonin (5-HT) receptor subtypes 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT6, and 5-HT7 (Kis = 0.03-3.98 nM).2 (±)-Asenapine inhibits the suppression of neuron firing induced by the 5-HT2A, dopamine D2, and α2-adrenergic receptor agonists 2,5-dimethoxy-4-iodoamphetamine (DOI), apomorphine, and clonidine , respectively, in rat brain (ED50s = 75, 40, and 85 μg/kg, respectively).1 In vivo, (±)-asenapine (0.05-0.2 mg/kg, s.c.) increases extracellular dopamine levels in the medial prefrontal cortex (mPFC), nucleus accumbens (NAc), and lateral striatum and suppresses the conditioned avoidance response in rats.3 It prevents acute and chronic phencyclidine-induced deficits in cued reversal learning in rats when administered at a dose of 0.075 mg/kg.4 Formulations containing asenapine have been used in the treatment of schizophrenia and bipolar I disorder. | | References | 1.Ghanbari, R., El Mansari, M., Shahid, M., et al.Electrophysiological characterization of the effects of asenapine at 5-HT1A, 5-HT2A, α2-adrenergic and D2 receptors in the rat brainEur. Neuropsychopharmacol.19(3)177-187(2009)
2.Shahid, M., Walker, G.B., Zorn, S.H., et al.Asenapine: A novel psychopharmacologic agent with a unique human receptor signatureJ. Psychopharmacol.23(1)65-73(2009)
3.Frnberg, O., Wiker, C., Marcus, M.M., et al.Asenapine, a novel psychopharmacologic agent: Preclinical evidence for clinical effects in schizophreniaPsychoparmacol.(Berl).196(3)417-429(2008)
4.McLean, S.L., Neill, J.C., Idris, N.F., et al.Effects of asenapine, olanzapine, and risperidone on psychotomimetic-induced reversal-learning deficits in the ratBehav. Brain Res.214(2)240-247(2010) |
| | Asenapine-13C-D3 hydrochloride Preparation Products And Raw materials |
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