Entereg-d5

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Entereg-d5 Basic information
Product Name:Entereg-d5
Synonyms:Avimopan Carboxylic acid metabolite D5;Alvimopan-d5 (R&D);ADL 8-2698-d5;AlviMopan-d5;Entereg-d5;LY 246736-d5;rac-N-[2-[[4-(3-Hydroxyphenyl)-3,4-diMethyl-1-piperidinyl]Methyl]-1-oxo-3-(phenyl-d5)propyl]glycine;[2H5]-Alvimopan (R&
CAS:1217616-62-0
MF:C25H32N2O4
MW:424.53258
EINECS:
Product Categories:Aromatics, Chiral Reagents, Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals
Mol File:1217616-62-0.mol
Entereg-d5 Structure
Entereg-d5 Chemical Properties
solubility DMSO: soluble
Methanol: soluble
Safety Information
MSDS Information
Entereg-d5 Usage And Synthesis
UsesLabelled Alvimopan. A peripheral μ-opioid receptor antagonist. Gastroprokinetic.
References[1] BERTRAND LE BOURDONNEC . Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as μ opioid receptor antagonists with improved opioid receptor selectivity profiles[J]. Bioorganic & Medicinal Chemistry Letters, 2008, 18 6: Pages 2006-2012. DOI: 10.1016/j.bmcl.2008.01.106
[2] B GREENWOOD-VAN MEERVELD. Preclinical studies of opioids and opioid antagonists on gastrointestinal function.[J]. Neurogastroenterology and Motility, 2004, 16 Suppl 2: 46-53. DOI: 10.1111/j.1743-3150.2004.00555.x
Entereg-d5 Preparation Products And Raw materials
Tag:Entereg-d5(1217616-62-0) Related Product Information
4-amino-5-ethylsulfonyl-2-methoxy-N-[[1-(1,1,2,2,2-pentadeuterioethyl)pyrrolidin-2-yl]methyl]benzamide fluMazenil iMpurity Alvimopan N-benzyl-N-(2-chloroethyl)-1-(2,3,4,5,6-pentadeuteriophenoxy)propan-2-amine:hydrochloride Doxylamine-d5 Succinate