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[2,2'-Binaphthalene]-1,1',4,4'-tetrone, 6,6',7,7'-tetrahydroxy-3,3'-diMethyl-5,5'-bis(1-Methylethyl)- Suppliers list
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
18210857532; 18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Apogossypolone
CAS:886578-07-0
Package:50Mg,5Mg
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| Company Name: |
Jinan Trio PharmaTech Co., Ltd.
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| Tel: |
0531-88811783 |
| Email: |
sales@trio-pharmatech.com |
| Products Intro: |
Product Name:Apogossypolone (ApoG2)
CAS:886578-07-0
Purity:99% Package:5Mg, 10Mg, 20Mg, 50Mg
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| Company Name: |
Nanjing JinruiJiuAn Biotechnology Co., Ltd.
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| Tel: |
025-58196018 800028039 |
| Email: |
sales@fartop.net |
| Products Intro: |
Product Name:[2,2'-Binaphthalene]-1,1',4,4'-tetrone, 6,6',7,7'-tetrahydroxy-3,3'-diMethyl-5,5'-bis(1-Methylethyl)-
CAS:886578-07-0
Purity:97%
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[2,2'-Binaphthalene]-1,1',4,4'-tetrone, 6,6',7,7'-tetrahydroxy-3,3'-diMethyl-5,5'-bis(1-Methylethyl)- manufacturers
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| | [2,2'-Binaphthalene]-1,1',4,4'-tetrone, 6,6',7,7'-tetrahydroxy-3,3'-diMethyl-5,5'-bis(1-Methylethyl)- Basic information |
| Product Name: | [2,2'-Binaphthalene]-1,1',4,4'-tetrone, 6,6',7,7'-tetrahydroxy-3,3'-diMethyl-5,5'-bis(1-Methylethyl)- | | Synonyms: | [2,2'-Binaphthalene]-1,1',4,4'-tetrone, 6,6',7,7'-tetrahydroxy-3,3'-diMethyl-5,5'-bis(1-Methylethyl)-;Apogossypolone (ApoG2);Gossypol Derivative ApoG2;APOG2;Apogossypolone | | CAS: | 886578-07-0 | | MF: | C28H26O8 | | MW: | 490.5 | | EINECS: | | | Product Categories: | | | Mol File: | 886578-07-0.mol | ![[2,2'-Binaphthalene]-1,1',4,4'-tetrone, 6,6',7,7'-tetrahydroxy-3,3'-diMethyl-5,5'-bis(1-Methylethyl)- Structure](CAS/GIF/886578-07-0.gif) |
| | [2,2'-Binaphthalene]-1,1',4,4'-tetrone, 6,6',7,7'-tetrahydroxy-3,3'-diMethyl-5,5'-bis(1-Methylethyl)- Chemical Properties |
| Melting point | >185°C (dec.) | | storage temp. | Refrigerator | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | Dark Yellow to Dark Orange |
| | [2,2'-Binaphthalene]-1,1',4,4'-tetrone, 6,6',7,7'-tetrahydroxy-3,3'-diMethyl-5,5'-bis(1-Methylethyl)- Usage And Synthesis |
| Uses | Apogossypolone is an anticancer agent that induces apoptosis in carcinoma cells. Antiproliferative. | | Biological Activity | apogossypolone is an inhibitor of bcl-2, mcl-1 and bcl-xl with ki values of 35nm, 25nm and 660nm, respectively [1].the mtt-based cell cytotoxicity assay shows that apogossypolone has an anticancer activity with ic50 values of 1, 2 and 3μm, respectively in pc-3, du-145 (human prostate cancer cell lines) and mda-mb-231(human breast cancer cell line). apogossypolone is also found to inhibit the colony formation of du-145 cells. the mechanism is that apogossypolone binds to bcl-2 and prevents its association with bh3-only pro-apoptotic proteins, leading the pro-apoptotic proteins to participate in the apoptotic response [2].besides prostate cancer and breast cancer, apogossypolone is also potent in follicular lymphoma. apogossypolone significantly inhibits the cell growth via inducing apoptosis in wsu-fsccl cell line with ic50 value of 109.2nm at 72h [3]. | | in vivo | Apogossypolone (ApoG2) (120 mg/kg; i.v. or p.o.; once a day for 5 days) effectively inhibits growth of diffuse large cell lymphoma cells without toxicity[1]. | Animal Model: | Four-week-old female ICR-SCID mice, each mouse received 107 WSU-DLCL2 cells (in serum-free RPMI 1640) subcutaneously (sc) in each flank area[1] | | Dosage: | 120 mg/kg | | Administration: | Intravenous or administration per day for five days | | Result: | Inhibited the growth of WSU-DLCL2 and significantly decreased the tumor weight. |
| Animal Model: | Non-tumor-bearing SCID mice[1] | | Dosage: | 160 mg/kg | | Administration: | Intravenous or administration per day for five days | | Result: | Was well tolerated in mice up to 800 mg/kg. Displayed no gross signs of toxicity. |
| | target | Bcl-2 | | IC 50 | Mcl-1: 25 nM (Ki); Bcl-2: 35 nM (Ki); Bcl-xL: 660 nM (Ki) | | references | [1] zhang xq, huang xf, hu xb, zhan yh, an qx, yang sm, xia aj, yi j, chen r, mu sj, wu dc. apogossypolone, a novel inhibitor of antiapoptotic bcl-2 family proteins, induces autophagy of pc-3 and lncap prostate cancer cells in vitro. asian j androl. 2010 sep;12(5):697-708.
[2] zhan y, jia g, wu d, xu y, xu l. design and synthesis of a gossypol derivative with improved antitumor activities. arch pharm (weinheim). 2009 apr;342(4):223-9.
[3] arnold aa, aboukameel a, chen j, yang d, wang s, al-katib a, mohammad rm. preclinical studies of apogossypolone: a new nonpeptidic pan small-molecule inhibitor of bcl-2, bcl-xl and mcl-1 proteins in follicular small cleaved cell lymphoma model. mol cancer. 2008 feb 14;7:20. |
| | [2,2'-Binaphthalene]-1,1',4,4'-tetrone, 6,6',7,7'-tetrahydroxy-3,3'-diMethyl-5,5'-bis(1-Methylethyl)- Preparation Products And Raw materials |
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