- Pamoic acid
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2026-04-25
- CAS:130-85-8
- Min. Order:
- Purity: 0.99
- Supply Ability:
- Pamoic acid
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- $0.00 / 1kg
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2026-04-23
- CAS:130-85-8
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 1000kg
- Pamoic acid
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- $0.00 / 1000KG
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2026-04-17
- CAS:130-85-8
- Min. Order: 1KG
- Purity: 0.99
- Supply Ability: 10T
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| | Pamoic acid Basic information |
| | Pamoic acid Chemical Properties |
| Melting point | ≥300 °C (dec.) | | Boiling point | 434.1°C (rough estimate) | | density | 1.2472 (rough estimate) | | refractive index | 1.4593 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Soluble in nitrobenzene, pyridine | | pka | 2.67±0.30(Predicted) | | form | Crystalline Powder | | color | Yellow to yellow-green | | Water Solubility | PRACTICALLY INSOLUBLE | | Merck | 14,7005 | | BRN | 901319 | | InChI | 1S/C23H16O6/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h1-10,24-25H,11H2,(H,26,27)(H,28,29) | | InChIKey | WLJNZVDCPSBLRP-UHFFFAOYSA-N | | SMILES | OC(=O)c1cc2ccccc2c(Cc3c(O)c(cc4ccccc34)C(O)=O)c1O | | CAS DataBase Reference | 130-85-8(CAS DataBase Reference) | | EPA Substance Registry System | 2-Naphthalenecarboxylic acid, 4,4'-methylenebis[3-hydroxy- (130-85-8) |
| | Pamoic acid Usage And Synthesis |
| Chemical Properties | Pamoic acid is yellow to yellow-green crystalline powder | | Uses | Agonist of the orphan G protein-coupled receptor GPR35: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Used as an inhibitor in the real-time
fluorescence enzymatic characterization study of specialized human DNA polymerases. | | Uses | Pamoic acid is used in preparation of repository derivatives of medicinal agents, used in pharmacology to increase the solubility of a drug in water. | | Definition | ChEBI: Pamoic acid is a dicarboxylic acid. It is functionally related to a 2-naphthoic acid. It is a conjugate acid of a pamoate(2-). | | General Description | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. | | Biological Activity | (1)Pamoic acid can inhibit Cas9 endonuclease activity. It effectively blocks bacterial or mammalian genome editing mediated by SpyCas9, SauCas9 or BE4 base editors at multiple endogenous gene loci. In addition, pamoic acid displays substrate competitive and PAM binding site occupancy mechanisms that selectively inhibit linear DNA cleavage compared to Cas9 cleavage of superhelical DNA. Importantly, pamoic acid pharmacologically modulates Cas9-mediated genome editing in mice.
(2)GPR35 activation by Pamoic acid may increase the phosphorylation of ERK1/2, which in turn initiates an anti-inflammatory signal by suppressing NF-κB-dependent inflammatory genes. | | Safety Profile | Poison by intraperitoneal route. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes. |
| | Pamoic acid Preparation Products And Raw materials |
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