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BOC Sciences |
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BMS-688521 manufacturers
- BMS-688521
-
- $116.00
-
2026-07-27
- CAS:893397-44-9
- Purity: 98.87%
- Supply Ability: 10g
- BMS-688521
-
- $116.00
-
2026-07-27
- CAS:893397-44-9
- Purity: 98.87%
- Supply Ability: 10g
|
| | BMS-688521 Basic information |
| Product Name: | BMS-688521 | | Synonyms: | BMS-688521;LILGMDXLRPEBNH-HFZDXXHNSA-N;6-[(5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4,4]non-7-yl]-3-pyridinecarboxylic acid;BMS688521,BMS 688521;3-Pyridinecarboxylic acid, 6-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl]-;BMS-688521, 10 mM in DMSO | | CAS: | 893397-44-9 | | MF: | C26H19Cl2N5O4 | | MW: | 536.37 | | EINECS: | | | Product Categories: | | | Mol File: | 893397-44-9.mol |  |
| | BMS-688521 Chemical Properties |
| Boiling point | 780.4±70.0 °C(Predicted) | | density | 1.60±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 2.87±0.10(Predicted) | | color | White to light yellow |
| | BMS-688521 Usage And Synthesis |
| Uses | BMS-688521 is a highly potent, orally active inhibitor of the LFA-1/ICAM interaction, with an IC50 of 2.5 nM in the adhesion assay and an IC50 of 60 nM in the MLR assay. BMS-688521 is efficacious in a mouse allergic eosinophilic lung inflammation model[1]. | | in vivo | BMS-688521 (1-10 mg/kg; p.o.; BID for a three-day) is efficacious in a mouse allergic eosinophilic lung inflammation model[1].
BMS-688521 (5 mg/kg; p.o.) treatment shows the Cmax, Tmax, AUC, F values are 0.32 μM, 1.0 μM, 1.5 μM h, and 50%, respectively[1].
BMS-688521 (1 mg/kg; i.v.) treatment shows the T1/2, MRT, CL and Vss values are 1.6 hours, 1.7 hours, 50 mL/mim/kg, and 5.1 L/kg, respectively in BALB/c mice[1]. | Animal Model: | BALB/c female mice, 6-8 week of age (OVA Lung Inflammation in Mice)[1] | | Dosage: | 1, 3, and 10 mg/kg | | Administration: | p.o.; BID for a three-day | | Result: | Significant inhibition of eosinophil accumulation was seen at a dose of 1 mg/kg BID, with dose-dependent inhibition at 3 mg/kg and 10 mg/kg. |
| | storage | Store at -20°C | | References | [1] Watterson SH, et al. Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4 DOI:10.1021/jm100348u |
| | BMS-688521 Preparation Products And Raw materials |
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