CC0651 manufacturers
- CC0651
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2026-05-11
- CAS:1319207-44-7
- Purity:
- Supply Ability: 10g
- CC0651
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- $3100.00
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2025-07-17
- CAS:1319207-44-7
- Purity:
- Supply Ability: 10g
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| Product Name: | CC0651 | | Synonyms: | (2R,3S,4S)-5-[4-(3,5-Dichlorophenyl)phenyl]-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid;L-Arabinonic acid, 4,5-dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]-;CC0651;4,5-Dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]-L-arabinonic acid;CC0651,CC-0651;Cdc34 Inhibitor, CC0651 | | CAS: | 1319207-44-7 | | MF: | C20H21Cl2NO6 | | MW: | 442.29 | | EINECS: | | | Product Categories: | | | Mol File: | 1319207-44-7.mol |  |
| | CC0651 Chemical Properties |
| Boiling point | 755.7±60.0 °C(Predicted) | | density | 1.410±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: ≥ 56 mg/mL (126.61 mM) | | pka | 3.37±0.34(Predicted) | | form | Powder | | color | White to off-white | | InChIKey | NTCBTNCWNRCBGX-YTQUADARSA-N | | SMILES | Clc1cc(cc(c1)c2ccc(cc2)C[C@H](NC(=O)COC)[C@H](O)[C@@H](O)C(=O)O)Cl |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | CC0651 Usage And Synthesis |
| Uses | CC0651 is an allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. CC0651 potently (IC50=1.72 μM) inhibits the ubiquitination of p27Kip1, as confirmed by dose-response analysis. | | General Description | A cell-permeable biphenylylpentanoic acid compound that acts as a selective allosteric inhibitor of E2 ubiquitin-conjugating enzyme Cdc34 (IC50 = 2.5 μM in a Sic1-SCFCdc4 assay) without affecting the activities of E1 or E3 ligases. Reported to act by trapping a weak interaction between ubiquitin and the E2 donor ubiquitin-binding site and may serve as a molecular bridge between Cdc34A and ubiquitin. Binds to Cdc34ACAT alone with an EC50 value of 267 μM, but in the presence of ubiquitin, this affinity is significantly increased (EC50 = 19 μM). Does not disrupt the interaction of Cdc34A with the RING domain of Rbx1 and is suggested to even moderately stabilize this interaction. Shown to inhibit p27Kip1 ubiquitination (IC50 = 1.72 μM) and reduce PC-3 cancer cells proliferation (~30 μM).
Please note that the molecular weight for this compound is batch-specific due to variable water content. | | Biochem/physiol Actions | Cell permeable: yes | | References | [1] Ceccarelli DF, et al. An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. Cell. 2011 Jun 24;145(7):1075-87. DOI:10.1016/j.cell.2011.05.039
[2] Huang H, et al. E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin. Nat Chem Biol. 2014 Feb;10(2):156-63. DOI:10.1038/nchembio.1412 |
| | CC0651 Preparation Products And Raw materials |
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