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| Product Name: | AMF-26 | | Synonyms: | AMF-26;(2E,4E)-5-[(1S,2S,4aR,6R,7S,8S,8aS)-7-hydroxy-2,6,8-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]-2-methyl-N-(pyridin-3-ylmethyl)penta-2,4-dienamide;2-Methylcoprophilinamide);M-COPA
(AMF-26;2,4-Pentadienamide, 2-methyl-5-[(1S,2S,4aR,6R,7S,8S,8aS)-1,2,4a,5,6,7,8,8a-octahydro-7-hydroxy-2,6,8-trimethyl-1-naphthalenyl]-N-(3-pyridinylmethyl)-, (2E,4E)-;M-COPA | | CAS: | 861718-91-4 | | MF: | C25H34N2O2 | | MW: | 394.55 | | EINECS: | | | Product Categories: | | | Mol File: | 861718-91-4.mol |  |
| | AMF-26 Chemical Properties |
| Boiling point | 608.5±55.0 °C(Predicted) | | density | 1.084±0.06 g/cm3(Predicted) | | pka | 14.01±0.46(Predicted) |
| | AMF-26 Usage And Synthesis |
| Enzyme inhibitor | This novel anticancer agent (FW = 403.55 g/mol), also known as (2E,4E)- 5-((1S,2S,4aR,6R,7S,8S,8aS)-7-hydroxy-2,6,8-trimethyl-1,2,4a,5,6,7,8,8aoctahydronaphthalen- 1-yl)-2-methyl-N-(pyridin-3-ylmethyl)penta-2,4- dienamide), is a powerful cell growth inhibitor (GI50 = 12 nM) and equally potent Golgi disruptor (EC50 = 27 nM), inhibiting activation of ADPribosylation factors (or Arfs) by its guanine nucleotide exchange factors (GEFs). Arfs are Ras superfamily small GTPases that play a major role in mediating vesicular transport in the secretory and endocytic pathways. Molecular dynamics (MD) simulations suggest that AMF-26 binds to the contact surface of the Arf1-Sec7 domain near the site for brefeldin A. AMF-26 strongly affected membrane traffic, including the cis-Golgi and trans-Golgi networks, and the endosomal systems. When tested with a panel of 39 cancer cell lines, the GI50 was consistently below 40 nM. The total synthesis of AMF-26 has also been described. |
| | AMF-26 Preparation Products And Raw materials |
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