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| | N-desMethyl EnzalutaMide Basic information |
| | N-desMethyl EnzalutaMide Chemical Properties |
| Melting point | >230oC (dec.) | | Boiling point | 572.4±60.0 °C(Predicted) | | density | 1.55±0.1 g/cm3(Predicted) | | storage temp. | Amber Vial, Refrigerator | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly, Heated) | | pka | 14.86±0.50(Predicted) | | form | Solid | | color | White to Off-White | | Stability: | Light Sensitive | | InChI | InChI=1S/C20H14F4N4O2S/c1-19(2)17(30)27(11-4-3-10(9-25)14(7-11)20(22,23)24)18(31)28(19)12-5-6-13(16(26)29)15(21)8-12/h3-8H,1-2H3,(H2,26,29) | | InChIKey | JSFOGZGIBIQRPU-UHFFFAOYSA-N | | SMILES | C(N)(=O)C1=CC=C(N2C(=S)N(C3=CC=C(C#N)C(C(F)(F)F)=C3)C(=O)C2(C)C)C=C1F |
| | N-desMethyl EnzalutaMide Usage And Synthesis |
| Uses | N-desMethyl EnzalutaMide is used in the treatment of disorders involving androgen, estrogen and progesterone receptors. | | Uses | 4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluorobenzamide is used in the treatment of disorders involving androgen, estrogen and progesterone receptors. | | Definition | ChEBI: N-desmethylenzalutamide is a benzamide obtained by formal condensation of the carboxy group of 4-{3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl}-2-fluorobenzoic acid with ammonia. It has a role as an antineoplastic agent and an androgen antagonist. It is a member of benzamides, an imidazolidinone, a nitrile, a thiocarbonyl compound, a member of (trifluoromethyl)benzenes and a member of monofluorobenzenes. | | in vivo | N-desmethyl Enzalutamide is an active metabolite that is thought to contribute to the clinical effects of Enzalutamide because it demonstrates primary and secondary pharmacodynamics of similar potency to Enzalutamide and circulates at approximately the same plasma concentrations as Enzalutamide. The carboxylic acid metabolite is pharmacologically inactive and circulates at approximately 25 % lower plasma concentrations than Enzalutamide[1]. |
| | N-desMethyl EnzalutaMide Preparation Products And Raw materials |
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