| Company Name: |
BOC Sciences |
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1-631-485-4226; 16314854226 |
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GLPG 0492 manufacturers
- GLPG0492
-
- $68.00
-
2026-07-27
- CAS:1215085-92-9
- Purity: 99.58%
- Supply Ability: 10g
- GLPG0492
-
- $68.00
-
2026-07-27
- CAS:1215085-92-9
- Purity: 99.58%
- Supply Ability: 10g
- GLPG0492
-
-
2023-09-05
- CAS:1215085-92-9
- Min. Order: 1kg
- Purity: 99.9%
- Supply Ability: 20tons
|
| | GLPG 0492 Basic information |
| Product Name: | GLPG 0492 | | Synonyms: | GLPG 0492;GLPG-0492
(GLPG0492);Benzonitrile, 4-[(4S)-4-(hydroxymethyl)-3-methyl-2,5-dioxo-4-phenyl-1-imidazolidinyl]-2-(trifluoromethyl)-;4-[(4S)-4-(Hydroxymethyl)-3-methyl-2,5-dioxo-4-phenyl-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile;GLPG0492, 10 mM in DMSO | | CAS: | 1215085-92-9 | | MF: | C19H14F3N3O3 | | MW: | 389.33 | | EINECS: | | | Product Categories: | | | Mol File: | 1215085-92-9.mol |  |
| | GLPG 0492 Chemical Properties |
| Melting point | 66 - 71°C | | Boiling point | 544.0±60.0 °C(Predicted) | | density | 1.50±0.1 g/cm3(Predicted) | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | DMSO (Slightly), Ethanol (Slightly, Sonicated) | | pka | 13.50±0.10(Predicted) | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic |
| | GLPG 0492 Usage And Synthesis |
| Description | GLPG0492 is a selective androgen receptor modulator (SARM). It activates the androgen receptor in a transactivation assay (EC50 = 12 nM in HeLa cells expressing the human receptor). GLPG0492 (10 mg/kg per day) increases levator ani muscle weight, a marker of anabolic activity, but has no effect on ventral prostate weight, a marker of androgenic activity, in castrated rats. It increases twitch tension in isolated diaphragm strips, as well as increases the total distance run in a treadmill test and decreases gastrocnemius muscle fibrosis in the exercised-mdx mouse model of muscular dystrophy when administered at a dose of 30 mg/kg. GLPG0492 also reverses immobilization-induced muscle atrophy in a mouse model of hindlimb immobilization. | | Uses | GLPG-0492 is a non-steroidal Selective Androgen Receptor Modulator (SARM), which can be used to reduce muscle loss while sparing reproductive tissues. | | References | [1] FRANOIS NIQUE. Identification of a 4-(Hydroxymethyl)diarylhydantoin as a Selective Androgen Receptor Modulator[J]. Journal of Medicinal Chemistry, 2012, 55 19: 8236-8247. DOI: 10.1021/jm300281x
[2] ANNA COZZOLI . GLPG0492, a novel selective androgen receptor modulator, improves muscle performance in the exercised-mdx mouse model of muscular dystrophy[J]. Pharmacological research, 2013, 72: Pages 9-24. DOI: 10.1016/j.phrs.2013.03.003
[3] ROLAND BLANQUé. Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization.[J]. BMC Musculoskeletal Disorders, 2014, 15: 291. DOI: 10.1186/1471-2474-15-291 |
| | GLPG 0492 Preparation Products And Raw materials |
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