| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
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| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:MRT-83
CAS:1263131-92-5
Purity:≥98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
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[1,1'-Biphenyl]-4-carboxaMide, N-[5-[[iMino[(3,4,5-triMethoxybenzoyl)aMino]Methyl]aMino]-2-Methylphenyl]- manufacturers
- MRT-83
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- $58.00 / 5mg
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2026-04-17
- CAS:1263131-92-5
- Min. Order:
- Purity: 99.92%
- Supply Ability: 10g
- MRT-83
-
- $58.00 / 5mg
-
2026-04-17
- CAS:1263131-92-5
- Min. Order:
- Purity: 99.92%
- Supply Ability: 10g
|
| | [1,1'-Biphenyl]-4-carboxaMide, N-[5-[[iMino[(3,4,5-triMethoxybenzoyl)aMino]Methyl]aMino]-2-Methylphenyl]- Basic information |
| Product Name: | [1,1'-Biphenyl]-4-carboxaMide, N-[5-[[iMino[(3,4,5-triMethoxybenzoyl)aMino]Methyl]aMino]-2-Methylphenyl]- | | Synonyms: | [1,1'-Biphenyl]-4-carboxaMide, N-[5-[[iMino[(3,4,5-triMethoxybenzoyl)aMino]Methyl]aMino]-2-Methylphenyl]-;MRT-83;N-[amino-[4-methyl-3-[(4-phenylbenzoyl)amino]anilino]methylidene]-3,4,5-trimethoxybenzamide;Inhibitor,MRT-83,MRT83,Smo,MRT 83,inhibit,Smoothened;N-(2-Methyl-5-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)-[1,1'-biphenyl]-4-carboxamide;MRT-83, 10 mM in DMSO;Hh Signaling Antagonist XII, MRT-83 | | CAS: | 1263131-92-5 | | MF: | C31H30N4O5 | | MW: | 538.5937 | | EINECS: | | | Product Categories: | | | Mol File: | 1263131-92-5.mol | ![[1,1'-Biphenyl]-4-carboxaMide, N-[5-[[iMino[(3,4,5-triMethoxybenzoyl)aMino]Methyl]aMino]-2-Methylphenyl]- Structure](CAS/20150408/GIF/1263131-92-5.gif) |
| | [1,1'-Biphenyl]-4-carboxaMide, N-[5-[[iMino[(3,4,5-triMethoxybenzoyl)aMino]Methyl]aMino]-2-Methylphenyl]- Chemical Properties |
| density | 1.22±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 10.29±0.46(Predicted) | | color | White to light yellow | | SMILES | O=C(NC(NC1=CC(NC(C2=CC=C(C3=CC=CC=C3)C=C2)=O)=C(C)C=C1)=N)C4=CC(OC)=C(C(OC)=C4)OC |
| WGK Germany | WGK 2 | | Storage Class | 11 - Combustible Solids |
| | [1,1'-Biphenyl]-4-carboxaMide, N-[5-[[iMino[(3,4,5-triMethoxybenzoyl)aMino]Methyl]aMino]-2-Methylphenyl]- Usage And Synthesis |
| Uses | MRT-83 is a novel potent antagonist of SMO, which has been shown to be useful for manipulating Hh signaling and may help develop new therapies against Hh-pathway related diseases. | | in vivo | Animals treated with ShhN in the presence of MRT-83 are as healthy as those of the other groups but up-regulation of Ptc transcription in the SVZ of these animals is no longer observed in agreement with a complete inhibition of ShhN-mediated effects (8.7±2.4 Ptc+ cells/section, n=9) and is not different from vehicle-mediated effects. MRT-83 but not MRT-36 antagonizes the up-regulation of Ptc transcription induced by ShhN in vivo in the SVZ of the LV[1]. |
| | [1,1'-Biphenyl]-4-carboxaMide, N-[5-[[iMino[(3,4,5-triMethoxybenzoyl)aMino]Methyl]aMino]-2-Methylphenyl]- Preparation Products And Raw materials |
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