173528-92-2
| 中文名称 | 173528-92-2 |
|---|---|
| 中文同义词 | HMN-154游离态;化合物HMN154;(E)-4-甲氧基-N-(2-(2-(吡啶-4-基)乙烯基)苯基)苯磺酰胺;化合物HMN154,10 MM DMSO 溶液 |
| 英文名称 | (E)-4-[2-{2-[N-(4-Methoxybenzenesulfonyl)aMino]phenyl}ethenyl ]pyridine |
| 英文同义词 | (E)-4-[2-{2-[N-(4-Methoxybenzenesulfonyl)aMino]phenyl}ethenyl ]pyridine;HMN-154;HMN 154;HMN154;2 AMINO 4 METHYL PYRIDINE AMINO PYRIDIN E;Benzenesulfonamide, 4-methoxy-N-[2-[(1E)-2-(4-pyridinyl)ethenyl]phenyl]-;(E)-4-Methoxy-N-(2-(2-(pyridin-4-yl)vinyl)phenyl)benzenesulfonamide;inhibit,Inhibitor,HMN-154,HMN 154;HMN-154, 10 mM in DMSO |
| CAS号 | 173528-92-2 |
| 分子式 | C20H18N2O3S |
| 分子量 | 366.43 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 173528-92-2.mol |
| 结构式 |  |
173528-92-2 性质
| 沸点 | 553.7±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.313±0.06 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | DMSO:15.0(最大浓度 mg/mL);40.93(最大浓度 mM) |
| 形态 | 固体 |
| 酸度系数(pKa) | 8.09±0.10(Predicted) |
| 颜色 | 白色至米白色 |
IC50: 0.0026 μg/mL (KB cells), 0.003 μg/mL (colon38 cells)
HMN-154 interacts with NF-YB and thereby interrupts the binding of the NF-Y heterotrimer to DNA. NF-YB and thymosin β-10 are specific cellular binding proteins of HMN-154 and that this shared region is necessary for the binding to HMN-154. HMN-154 inhibits DNA binding of NF-Y to the human major histocompatibility complex class II human leukocyte antigen DRA Y-box sequence in a dose-dependent manner. HMN-154 shows very strong cytotoxicity against KB and colon38 cells with an IC 50 value of 0.0026 and 0.003 μg/mL, respectively. HMN-154/BSA binds recombinant NF-YB or thymosin β-10 and the binding is inhibited by the addition of HMN-154 as the competitor. The binding between HMN-154 and NF-YB is specific and depends on its cytotoxicity.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2023/01/06 | S0288 | 173528-92-2 HMN-154 | 173528-92-2 | 5mg | 3824.73元 |
| 2023/01/06 | S0288 | 173528-92-2 HMN-154 | 173528-92-2 | 25mg | 11539.7元 |