|
|
| | PD 150,606 Basic information |
| Product Name: | PD 150,606 | | Synonyms: | 3-(4-Iodophenyl)-2-mercapto-2-propenoic acid;2-Propenoic acid, 3-(4-iodophenyl)-2-mercapto- | | CAS: | 426821-41-2 | | MF: | C9H7IO2S | | MW: | 306.12 | | EINECS: | | | Product Categories: | | | Mol File: | 426821-41-2.mol |  |
| | PD 150,606 Chemical Properties |
| storage temp. | -20°C | | solubility | DMSO: 100mg/mL
methanol: 25mg/mL | | form | solid | | color | Off-white |
| Risk Statements | 25-37/38-41-43 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 2811 6.1 / PGIII | | WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | PD 150,606 Usage And Synthesis |
| Uses | A cell-permeable, non-competitive, selective non-peptide calpain inhibitor [Ki = 210 nM for calpain-1 and 370 nM for calpain-2] directed towards the calcium binding sites of calpain. Exhibits high specificity for calpains relative to other proteases, such as cathepsin B and cathepsin L. Does not shield calpain against inactivation by the active-site inhibitor trans-(epoxysuccinyl)-L-leucyl-amido-3-methylbutane. Reportedly prevents dexamethasone-induced apoptosis in thymocytes.
A cell-permeable, selective non-peptide calpain inhibitor (Ki = 210 nM for calpain I and 370 nM for calpain II) directed towards the calcium- binding sites of calpain. Exhibits high specificity for calpains relative to other proteases, such as cathepsin B and L. PD 150606 is a non-competitive inhibitor with respect to the substrate and does not shield calpain against inactivation by the active-site inhibitor trans-(epoxysuccinyl)-L-leucyl-amido-3-methylbutane. Reportedly prevents dexamethasone-induced apoptosis of thymocytes. | | Definition | ChEBI: (Z)-3-(4-iodophenyl)-2-mercaptoacrylic acid is an organoiodine compound that is acrylic acid in which the vinylic hydrogens at positions 2 and 3 are replaced by mercapto and 4-iodophenyl groups respectively (the Z geoisomer). It has a role as a calpain inhibitor and an apoptosis inhibitor. It is an organoiodine compound, a member of cinnamic acids and a thioenol. It is functionally related to a trans-cinnamic acid. | | Biological Activity | Cell permeable: yes', 'Primary Target
Calpain-1', 'Product does not compete with ATP.', 'Reversible: no', 'Target Ki: 210 nM for calpain-1 and 370 nM for calpain-2 | | storage | +4°C |
| | PD 150,606 Preparation Products And Raw materials |
|