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| | 4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline Basic information |
| Product Name: | 4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline | | Synonyms: | 4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline;Ethyl 4-chloro-1,2-dihydro-1-methyl-2-oxoquinoline-3-carboxylate;4-Chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester;Nrf2 Activator II, AI-1;AI-1
(Nrf2 acticatior AI-1);Nrf2 Activator II, AI-1 - CAS 75483-04-4 - Calbiochem;AI-1 >=98% (HPLC);3-Quinolinecarboxylic acid, 4-chloro-1,2-dihydro-1-methyl-2-oxo-, ethyl ester | | CAS: | 75483-04-4 | | MF: | C13H12ClNO3 | | MW: | 265.69 | | EINECS: | | | Product Categories: | | | Mol File: | 75483-04-4.mol |  |
| | 4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline Chemical Properties |
| Melting point | 90-92 °C | | Boiling point | 358.7±42.0 °C(Predicted) | | density | 1.34±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: ≥15mg/mL | | form | powder | | pka | -2.22±0.60(Predicted) | | color | white to tan | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. | | InChI | 1S/C13H12ClNO3/c1-3-18-13(17)10-11(14)8-6-4-5-7-9(8)15(2)12(10)16/h4-7H,3H2,1-2H3 | | InChIKey | XUJQDJGGHFNYDY-UHFFFAOYSA-N | | SMILES | Clc1c2c([n]([c](c1C(=O)OCC)=O)C)cccc2 |
| Hazard Codes | Xi | | Risk Statements | 43 | | Safety Statements | 36/37 | | WGK Germany | WGK 3 | | HS Code | 2933499090 | | Storage Class | 11 - Combustible Solids |
| | 4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline Usage And Synthesis |
| Description | AI-1 (75483-04-4) is a novel antioxidant response element (ARE) activator which activates Nrf2 by covalently modifying Keap1 (Kelch-like ECH-associated protein 1) a negative regulator of Nrf2. Modification of Cys151 of Keap1 by AI-1 disrupts the ability of Keap1 to serve as an adaptor for Cul3-Keap1 ubiquitin ligase complex, thereby stabilizing and inducing transcriptional activation of Nrf2. AI-1 is a useful pharmacological tool for probing the involvement of Nrf2 in cellular physiology.1Cell permeable. | | Uses | AI-1 is an antioxidant response element (ARE) that activates Nrf2 by covalently modifying Keap1. AI-1 is a useful pharmacological probe for investigating the molecular details of the cellular antioxidant response. | | References | [1] WOOYOUNG HUR. A small-molecule inducer of the antioxidant response element.[J]. Chemistry & biology, 2010, 17 5: 537-547. DOI:10.1016/j.chembiol.2010.03.013 |
| | 4-Chloro-1,2-dihydro-3-(ethoxycarbonyl)-1-methyl-2-oxoquinoline Preparation Products And Raw materials |
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