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| | 2-(4-CHLORO-PHENYL)-CYCLOPROPANECARBOXYLIC ACID Basic information |
| Product Name: | 2-(4-CHLORO-PHENYL)-CYCLOPROPANECARBOXYLIC ACID | | Synonyms: | NSC 40845;2-(4-Chlorophenyl);ART-CHEM-BB B006809;AKOS B006809;2-(4-CHLORO-PHENYL)-CYCLOPROPANECARBOXYLIC ACID;2-(4-chlorophenyl)cyclopropane-1-carboxylic acid;trans-2-(4-chlorophenyl)cyclopropane-1-carboxylic acid;Cyclopropanecarboxylic acid, 2-(4-chlorophenyl)- | | CAS: | 90940-40-2 | | MF: | C10H9ClO2 | | MW: | 196.63 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | 2-(4-CHLORO-PHENYL)-CYCLOPROPANECARBOXYLIC ACID Chemical Properties |
| Melting point | 112 °C | | Boiling point | 346.9±42.0 °C(Predicted) | | density | 1.388±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 4.53±0.10(Predicted) | | Appearance | White to off-white Solid | | Optical Rotation | 0.1°(C=0.46g/ml, CHCL3 , 20°C, 589nm) |
| Hazard Codes | Xi,T | | Risk Statements | 25 | | Safety Statements | 45 | | HazardClass | IRRITANT | | HS Code | 2916399090 |
| | 2-(4-CHLORO-PHENYL)-CYCLOPROPANECARBOXYLIC ACID Usage And Synthesis |
| Synthesis | GENERAL METHOD: 1 g of NaOH (25 mmol) was dissolved in 4 cm3 of a solvent mixture of EtOH/HO (85/15; v/v) and cooled to the appropriate temperature. Subsequently, 9 cm3 EtOH solution containing ester 18-20 (2.21 mmol) was added. The reaction mixture was stirred continuously for 5 hours at room temperature. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in 30 cm3 water and the aqueous layer was washed with 2 x 15 cm3 CHCl The aqueous layer was subsequently acidified with concentrated HCl and extracted with 3 x 15 cm3 CHCl All organic layers were combined, dried with NaSO and finally evaporated to dryness. | | References | [1] Monatshefte fur Chemie, 2017, vol. 148, # 12, p. 2143 - 2153
[2] Bulletin de la Societe Chimique de France, 1960, p. 304 - 312
[3] Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1957, vol. 245, p. 2304
[4] Bulletin de la Societe Chimique de France, 1960, p. 304,307, 308 |
| | 2-(4-CHLORO-PHENYL)-CYCLOPROPANECARBOXYLIC ACID Preparation Products And Raw materials |
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