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| | 4-Hydroxyalternariol Basic information |
| Product Name: | 4-Hydroxyalternariol | | Synonyms: | 4-Hydroxyalternariol;Hydroxyalternariol, 4-;3,4,7,9-tetrahydroxy-1-methylbenzo[c]chromen-6-one;6H-Dibenzo[b,d]pyran-6-one, 3,4,7,9-tetrahydroxy-1-methyl-;Alternariol Impurity 18;3,4,7,9-tetrahydroxy-1-methyl-6H-dibenzo[b,d]pyran-6-one | | CAS: | 959417-21-1 | | MF: | C14H10O6 | | MW: | 274.23 | | EINECS: | | | Product Categories: | | | Mol File: | 959417-21-1.mol |  |
| | 4-Hydroxyalternariol Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble | | form | A solid |
| | 4-Hydroxyalternariol Usage And Synthesis |
| Description | 4-hydroxy Alternariol is a metabolite of the mycotoxin alternariol formed through cytochrome P450 (CYP450) metabolism. It increases reactive oxygen species (ROS) in KYSE510 human esophageal cells by 701% compared to control. 4-hydroxy Alternariol increases topoisomerase IIβ-DNA complexes by 208% compared to control in an ICE assay but does not induce DNA damage in KYSE510 cells. It completely inhibits topoisomerase IIα activity at a concentration of 25 μM under cell-free conditions. | | Uses | 4-Hydroxyalternariol is the fully demethylated tetraphenol analogue of the benzopyranone graphislactones. Hydroxyalternariol was isolated as a major co-metabolite of a graphislactone A-producing fungus. Hydroxyalternariol has not previously been available for study and no bioactivity has been reported to date. | | Uses | 4-Hydroxy Alternariol is a derivative of Alternariol (A575760). Alternariol is an alternaria mycotoxin and genotoxin, found in common edible crops. It inhibits the activity of various DNA-topoisomerases, increasing the rate of DNA strand breaks. | | References | [1] E PFEIFFER. Activities of human recombinant cytochrome P450 isoforms and human hepatic microsomes for the hydroxylation ofAlternaria toxins.[J]. Mycotoxin Research, 2008, 24 3: 117-123. DOI: 10.1007/bf03032337
[2] CHRISTINE TIESSEN. Impact of phase I metabolism on uptake, oxidative stress and genotoxicity of the emerging mycotoxin alternariol and its monomethyl ether in esophageal cells[J]. Archives of Toxicology, 2016, 91 3: 1213-1226. DOI: 10.1007/s00204-016-1801-0 |
| | 4-Hydroxyalternariol Preparation Products And Raw materials |
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