- SELEXIPAG interMediate
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- $35.00 / 1kg
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2025-09-25
- CAS:475086-75-0
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
- SELEXIPAG interMediate
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- $2.00 / 1KG
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2019-07-06
- CAS:475086-75-0
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 200KG
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| | SELEXIPAG interMediate Basic information |
| Product Name: | SELEXIPAG interMediate | | Synonyms: | SELEXIPAG interMediate;4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]-1-Butanol;Selexipag intermediates;1-Butanol, 4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]-;1-Butanol, 4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]-;4-[(5,6-Diphenylpyrazinyl)(1-methylethyl)amino]-1-butanol;-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]-1-Butanol;4-((5,6-Diphenylpyrazin-2-yl)(isopropyl)amino)butan-1-ol | | CAS: | 475086-75-0 | | MF: | C23H27N3O | | MW: | 361.48 | | EINECS: | 813-799-3 | | Product Categories: | selexipag;non-prostanoid prostacyclin (PGI2) receptor agonist | | Mol File: | 475086-75-0.mol |  |
| | SELEXIPAG interMediate Chemical Properties |
| Melting point | 68 - 71°C | | Boiling point | 514.4±50.0 °C(Predicted) | | density | 1.112±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), DMSO (Slightly) | | form | Solid | | pka | 15.05±0.10(Predicted) | | color | Pale Yellow to Light Yellow | | InChI | InChI=1S/C23H27N3O/c1-18(2)26(15-9-10-16-27)21-17-24-22(19-11-5-3-6-12-19)23(25-21)20-13-7-4-8-14-20/h3-8,11-14,17-18,27H,9-10,15-16H2,1-2H3 | | InChIKey | PKBSUZWFQXNCSI-UHFFFAOYSA-N | | SMILES | C(O)CCCN(C1=NC(C2=CC=CC=C2)=C(C2=CC=CC=C2)N=C1)C(C)C |
| | SELEXIPAG interMediate Usage And Synthesis |
| Uses | 4-[(5,6-Diphenyl-2-pyrazinyl)(1-methylethyl)amino]-1-butanol is a diphenylpyrazine derivative which belongs to a class of prostacyclin receptor agonists. It is an impurity of Selexipag (S253150) that is a potential drug for the treatment of various vascular disorders such as pulmonary arterial hypertension and arteriosclerosis obliterans. | | Application | Selexipag interMediate is a synthetic organic compound that is used as an intermediate in the synthesis of oxychloride. It is an oxychloride with a nucleophilic substitution reaction. The reaction proceeds selectively at the phosphorus atom and gives high yield. The reactivity of 4-[(5,6-diphenylpyrazin-2-yl)(propan-2-yl)amino]butan-1-ol is enhanced by the use of n butanol, which also acts as a solvent for the reaction. The product can be purified by filtration or recrystallization from hexane with piperazine as a reagent. |
| | SELEXIPAG interMediate Preparation Products And Raw materials |
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