| Company Name: |
BePharm Ltd |
| Tel: |
400-685-9117 |
| Email: |
market@bepharm.com |
|
| | 3-(Benzyloxy)benzene-1,2-diaMine Basic information |
| | 3-(Benzyloxy)benzene-1,2-diaMine Chemical Properties |
| Boiling point | 402.4±30.0 °C(Predicted) | | density | 1.199±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 4.33±0.10(Predicted) | | Appearance | Brown to black Powder |
| | 3-(Benzyloxy)benzene-1,2-diaMine Usage And Synthesis |
| Synthesis | Under nitrogen protection, 2-(benzyloxy)-6-nitroaniline (5 g, 0.02 mol) was dissolved in a mixed solution of acetic acid (50 mL) and ethanol (50 mL) and stirred at 15 °C. To this solution was added iron powder (4.6 g, 0.08 mol). The reaction mixture was heated to 75°C and stirred continuously for 30 minutes. After completion of the reaction, the mixture was concentrated under vacuum. The concentrated residue was dissolved in water (50 mL) and the pH was adjusted with saturated sodium bicarbonate solution to 9. Subsequently, the aqueous phase was extracted with ethyl acetate (50 mL x 3). The organic phases were combined, washed with brine (50 mL), dried over anhydrous sodium sulfate, and concentrated under vacuum. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate) to give 3-(benzyloxy)benzene-1,2-diamine (2.2 g, 77.7% yield) as a yellow oil.LCMS (M+H+) m/z: calculated value 215.12; measured value 215.1. | | References | [1] Patent: WO2016/200840, 2016, A1. Location in patent: Page/Page column 405; 406
[2] Journal of Medicinal Chemistry, 2018, vol. 61, # 8, p. 3309 - 3324
[3] Archives of Pharmacal Research, 2017, vol. 40, # 4, p. 469 - 479
[4] Journal of Heterocyclic Chemistry, 1983, vol. 20, # 6, p. 1525 - 1532
[5] Patent: WO2009/24825, 2009, A1. Location in patent: Page/Page column 132 |
| | 3-(Benzyloxy)benzene-1,2-diaMine Preparation Products And Raw materials |
|