| Company Name: |
Lynnchem |
| Tel: |
86-(0)29-85992781 17792393971 |
| Email: |
info@lynnchem.com |
8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one manufacturers
- FQI 1
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- $48.00
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2026-04-29
- CAS:599151-35-6
- Purity: 98.69%
- Supply Ability: 10g
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| | 8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one Basic information |
| Product Name: | 8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one | | Synonyms: | FQI1
(FQI 1);8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one;FQI1;8-(2-ethoxyphenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one;FQI1 >=98% (HPLC);1,3-Dioxolo[4,5-g]quinolin-6(5H)-one, 8-(2-ethoxyphenyl)-7,8-dihydro- | | CAS: | 599151-35-6 | | MF: | C18H17NO4 | | MW: | 311.33 | | EINECS: | | | Product Categories: | | | Mol File: | 599151-35-6.mol | ![8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one Structure](CAS/20180702/GIF/599151-35-6.gif) |
| | 8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one Chemical Properties |
| Boiling point | 463.6±45.0 °C(Predicted) | | density | 1.272±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble10mg/mL (clear solution) | | form | powder | | pka | 13.36±0.40(Predicted) | | color | white to beige | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. | | InChI | 1S/C18H17NO4/c1-2-21-15-6-4-3-5-11(15)12-8-18(20)19-14-9-17-16(7-13(12)14)22-10-23-17/h3-7,9,12H,2,8,10H2,1H3,(H,19,20) | | InChIKey | YKSYGLXHLSPWLB-UHFFFAOYSA-N | | SMILES | O=C1CC(C2=CC=CC=C2OCC)C3=CC4=C(OCO4)C=C3N1 |
| Hazard Codes | T,N | | Risk Statements | 25-50 | | Safety Statements | 45-61 | | RIDADR | UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | 8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one Usage And Synthesis |
| Description | FQI1 (599151-35-6) is an inhibitor of transcription factor LSF specifically targeting its DNA binding and corresponding transcriptional activity (IC50=2.1 μM). Rapidly induces apoptosis in an aggressive hepatocellular carcinoma (HCC) cell line and dramatically inhibits tumor growth in a mouse xenograft model with no general tissue cytotoxicity.1,2In human HCC cells, FQI1 induced mitotic arrest with an accompanying increase in cyclin B1.3Blocks LSF-stimulated activation of DNA methyltransferase 1.4Cell permeable. | | Uses | FQI1 is a Late SV40 Factor (LSF) inhibitor. FQI1 inhibits cell proliferation, with IC50s of 3, 0.79, 6.3 μM for NIH/3T3, HeLa, A549 cells. FQI1 can be used for cancer research[1]. | | References | [1] TREVOR J GRANT. Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2012: 4503-4508. DOI:10.1073/pnas.1121601109
[2] PRASANNA K SANTHEKADUR. The transcription factor LSF: a novel oncogene for hepatocellular carcinoma.[J]. American journal of cancer research, 2012, 2 3: 269-285.
[3] DEVARAJA RAJASEKARAN. Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model.[J]. Oncotarget, 2015: 26266-26277. DOI:10.18632/oncotarget.4656
[4] H. CHIN. Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression[J]. Oncotarget, 2016, 7 1: 83627-83640. DOI:10.18632/oncotarget.13271 |
| | 8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one Preparation Products And Raw materials |
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