| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:SB 328437;N-(1-Naphthalenylcarbonyl)-4-nitro-L-phenylalanineMethylester
CAS:247580-43-4
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Guangzhou Isun Pharmaceutical Co., Ltd
|
| Tel: |
020-39119399 18927568969 |
| Email: |
isunpharm@qq.com |
| Products Intro: |
Product Name:Methyl (2S)-2-(1-naphthoylaMino)-3-(4-nitrophenyl)propanoate
CAS:247580-43-4
Purity:>=98% (HPLC) Package:5Mg;25Mg;50Mg;250Mg;1g;2g;5g;25g
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(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE manufacturers
- SB 328437
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- $79.00 / 5mg
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2026-03-13
- CAS:247580-43-4
- Min. Order:
- Purity: 99.54%
- Supply Ability: 10g
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| | (S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE Basic information |
| Product Name: | (S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE | | Synonyms: | SB 328437;(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE;SB 328437 - CAS 247580-43-4 - Calbiochem;N-(1-Naphthalenylcarbonyl)-4-nitro-L-phenylalaninemethylester;Methyl (2S)-2-(1-naphthoylaMino)-3-(4-nitrophenyl)propanoate;L-Phenylalanine, N-(1-naphthalenylcarbonyl)-4-nitro-, methyl ester;SB 328437 >=98% (HPLC);Methyl (S)-2-(1-naphthamido)-3-(4-nitrophenyl)propanoate | | CAS: | 247580-43-4 | | MF: | C21H18N2O5 | | MW: | 378.38 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | (S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE Chemical Properties |
| Boiling point | 642.9±50.0 °C(Predicted) | | density | 1.305±0.06 g/cm3(Predicted) | | storage temp. | Store at +4°C | | solubility | DMSO: ≥10mg/mL | | form | White solid | | pka | 12.51±0.46(Predicted) | | color | white to tan | | InChI | 1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1 | | InChIKey | VMFGCGRAIBLAFY-IBGZPJMESA-N | | SMILES | COC(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)NC(=O)c2cccc3ccccc23 |
| Hazard Codes | Xn,N | | Risk Statements | 22-50 | | Safety Statements | 60-61 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | (S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE Usage And Synthesis |
| Uses | SB 328437 is a potent and selective CCR3 receptor antagonist. | | Biological Activity | SB 328437 inhibits the recruitment and migration of eosinophils in allergen models of models. It suppresses the Th2-mediated eosinophil infiltration in the airways.', 'SB-328437 is a potent, selective CCR-3 antagonist (IC50 = 1.6 nM). The compound blockes CCR3 agonist-induced calcium mobilization in CCR3 expressing cells with the following IC50 values: eotaxin, 38 nM; eotaxin-2, 35 nM and MCP4, 20 nM. | | in vivo | SB-328437 (intraperitoneal injection; 5 g/kg; single dose) has a beneficial effect in mouse models of LPS (HY-D1056)-induced lung injury and influenza virus infection[2]. | Animal Model: | Influenza A strain pmd09 treated C57BL/6 female mice aged 8-10 weeks old (18-20 g) [2] | | Dosage: | 5 g/kg | | Administration: | Intraperitoneal injection (i.p.); single dose | | Result: | Reduced neutrophil recruitment to the lung alveolar space.
Reduced tissue damage.
Reduced lung inflammation and the expression of pro-inflammatory cytokines, Tnfa and Cxcl1.
Decreased the activation level of neutrophils.
Lowered the viral load in mice.
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| | IC 50 | CCR3: 4.5 nM (IC50) | | storage | Store at +4°C |
| | (S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE Preparation Products And Raw materials |
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