- 6-Bromoisatin
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- $36.00
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2026-09-02
- CAS:6326-79-0
- Min. Order: 1kg
- Purity: 99%
- 6-Bromoisatin
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-
2026-05-18
- CAS:6326-79-0
- Min. Order: 1kg
- Purity: 98%
- 6-Bromoisatin
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- $10.00
-
2025-05-23
- CAS:6326-79-0
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20 ton
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| | 6-Bromoisatin Basic information |
| | 6-Bromoisatin Chemical Properties |
| Melting point | 274°C | | density | 1.826±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 8.83±0.20(Predicted) | | color | Dark Yellow | | InChI | InChI=1S/C8H4BrNO2/c9-4-1-2-5-6(3-4)10-8(12)7(5)11/h1-3H,(H,10,11,12) | | InChIKey | HVPQMLZLINVIHW-UHFFFAOYSA-N | | SMILES | N1C2=C(C=CC(Br)=C2)C(=O)C1=O | | CAS DataBase Reference | 6326-79-0(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 22-41-43 | | Safety Statements | 22-24/25-36/37/39-26 | | WGK Germany | WGK 3 | | HazardClass | IRRITANT | | HS Code | 2933998090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2 |
| | 6-Bromoisatin Usage And Synthesis |
| Chemical Properties | Orange Powder | | Uses | Antimicrobial | | Biological Functions |
6-Bromoisatin inhibited proliferation of HT29 cells at IC50 223 μM (0.05 mg/mL) and induced apoptosis without increasing caspase 3/7 activity. In vivo 6-bromoisatin (0.05 mg/g) was found to significantly enhance the apoptotic index (p ≤ 0.001) and reduced cell proliferation (p ≤ 0.01) in the distal colon.
| | Synthesis | Step 2: N-(3-bromophenyl)-2-hydroxyiminoacetamide (55 g, 0.2272 mol) was added to concentrated sulfuric acid (275 mL) and the temperature was maintained at 50 °C. The temperature of the reaction system was then raised to 90 °C for 3 hours. Upon completion of the reaction, the reaction mixture was slowly poured into ice water and a yellow precipitate was precipitated. The precipitate was collected by filtration and dried to give 6-bromodihydroindole-2,3-dione as a yellow solid (50 g, 98% yield). The resulting product can be used directly in the subsequent reaction without further purification. | | Purification Methods | 6-Bromoisatin recrystallises from AcOH (yellow needles). It is a plant growth substance. IR in CHCl3 has 1320 and 3440cm-1. [Sadler J Org max Chem 21 169 1956, Beilstein 21 III/IV 5012.] | | References | [1] Patent: WO2012/58671, 2012, A1. Location in patent: Page/Page column 91
[2] Patent: WO2011/119704, 2011, A1. Location in patent: Page/Page column 36-37
[3] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 5, p. 549 - 554
[4] Medicinal Chemistry, 2014, vol. 10, # 5, p. 484 - 496
[5] Patent: US2014/38952, 2014, A1. Location in patent: Page/Page column 0154-0155 |
| | 6-Bromoisatin Preparation Products And Raw materials |
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