- THK-523
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- $2500.00
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2026-04-20
- CAS:1573029-17-0
- Purity:
- Supply Ability: 10g
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| | THK-523 Basic information |
| Product Name: | THK-523 | | Synonyms: | 4-(6-(2-fluoroethoxy)quinolin-2-yl)aniline;THK-523;4-[6-(2-Fluoroethoxy)-2-quinolinyl]benzenamine;Benzenamine, 4-[6-(2-fluoroethoxy)-2-quinolinyl]- | | CAS: | 1573029-17-0 | | MF: | C17H15FN2O | | MW: | 282.31 | | EINECS: | | | Product Categories: | | | Mol File: | 1573029-17-0.mol |  |
| | THK-523 Chemical Properties |
| Boiling point | 470.3±45.0 °C(Predicted) | | density | 1.225±0.06 g/cm3(Predicted) | | pka | 4.45±0.30(Predicted) |
| | THK-523 Usage And Synthesis |
| Description | THK-523 is a selective Tau ligand, selectively binding to neurofibrillary tangles and neuropils in people with Alzheimer's disease. | | Uses | THK-523 has demonstrated its high affinity and selectivity for tau pathology both in vitro and in vivo. 18F-THK523 is a potent tau imaging radiotracer. 18F-THK523 is a potent in vivo tau imaging ligand for Alzheimer's disease[1]. | | in vivo | THK-523 crosses the blood-brain barrier in mice and the in vivo retention rate in the brain of Tau transgenic mice increased[1]. | Animal Model: | Brain of tau transgenic mice[1] | | Dosage: | 0.35 μg/kg | | Administration: | Intravenous injection;25-30 mins | | Result: | Overexpressed Tau in brain. |
| | References | [1] Ryuichi Harada, et al. Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology. Eur J Nucl Med Mol Imaging.2013 Jan;40(1):125-32. DOI:10.1007/s00259-012-2261-2
[2] Michelle T Fodero-Tavoletti,18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease. Brain.2011 Apr;134(Pt 4):1089-100. DOI:10.1093/brain/awr038 |
| | THK-523 Preparation Products And Raw materials |
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