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| | Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylate Basic information |
| | Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylate Chemical Properties |
| Boiling point | 334.5±37.0 °C(Predicted) | | density | 1.403±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 13.56±0.30(Predicted) | | Appearance | Off-white to light yellow Solid | | InChI | InChI=1S/C11H8F3NO2/c1-17-10(16)9-5-6-7(11(12,13)14)3-2-4-8(6)15-9/h2-5,15H,1H3 | | InChIKey | HEEQKKQXILYZNF-UHFFFAOYSA-N | | SMILES | N1C2=C(C(C(F)(F)F)=CC=C2)C=C1C(OC)=O |
| | Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylate Usage And Synthesis |
| Synthesis | General procedure: methyl 2-azido-3-[2-(trifluoromethyl)phenyl]prop-2-enoate (20.0 mmol) was added to preheated xylene (75 mL) in one go, and the reaction was kept at reflux for 2 hours. After completion of the reaction, the solvent was removed by rotary evaporator and the resulting crude product was purified by silica gel column chromatography with the eluent being a mixed petroleum ether/ethyl acetate solvent. The synthesis of compound 4-(trifluoromethyl)-1H-indole-2-carboxylic acid methyl ester was carried out with reference to the methods reported in literature [9b], [13] and [14]. | | References | [1] European Journal of Medicinal Chemistry, 2012, vol. 49, p. 379 - 396 |
| | Methyl 4-(trifluoromethyl)-1H-indole-2-carboxylate Preparation Products And Raw materials |
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