| Company Name: |
BePharm Ltd |
| Tel: |
400-685-9117 |
| Email: |
market@bepharm.com |
|
| | 5-Chloropyrazolo[1,5-a]pyrimidin-7(1H)-one Basic information |
| | 5-Chloropyrazolo[1,5-a]pyrimidin-7(1H)-one Chemical Properties |
| Melting point | 298-300 °C (decomp) | | Boiling point | 302.4±52.0 °C(Predicted) | | density | 1.71±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | -2.58±0.40(Predicted) | | form | solid | | Appearance | White to off-white Solid | | InChI | 1S/C6H4ClN3O/c7-4-3-6(11)10-5(9-4)1-2-8-10/h1-3,9H | | InChIKey | QNNBWYYLICBZOI-UHFFFAOYSA-N |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Aquatic Chronic 1
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1 |
| | 5-Chloropyrazolo[1,5-a]pyrimidin-7(1H)-one Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 5-chloropyrazolo[1,5-a]pyrimidin-7(1H)-ones from 5,7-dichloropyrazolo[1,5-a]pyrimidines: 1 g of 5,7-dichloropyrazolo[1,5-a]pyrimidines was suspended in 25 mL of 1 N aqueous sodium hydroxide solution, heated to 90 °C and stirred for 0.5 h. The reaction was carried out by thin layer chromatography (TLC). The progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the reaction mixture was cooled to room temperature. The pH was adjusted to 2 with 1N HCl solution to form a suspension. 5-Chloropyrazolo[1,5-a]pyrimidin-7(1H)-one (0.9 g, 99% yield) was obtained by filtration after standing. | | References | [1] Patent: CN107033149, 2017, A. Location in patent: Paragraph 0110; 0180-0181
[2] Journal of Heterocyclic Chemistry, 1985, vol. 22, # 3, p. 601 - 634 |
| | 5-Chloropyrazolo[1,5-a]pyrimidin-7(1H)-one Preparation Products And Raw materials |
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