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| Company Name: |
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ABT-100 manufacturers
- ABT-100
-
- $977.00
-
2026-07-16
- CAS:450839-40-4
- Purity:
- Supply Ability: 10g
- ABT-100
-
- $977.00
-
2026-07-15
- CAS:450839-40-4
- Purity:
- Supply Ability: 10g
- ABT-100
-
- $977.00
-
2026-01-05
- CAS:450839-40-4
- Purity:
- Supply Ability: 10g
|
| | ABT-100 Basic information |
| Product Name: | ABT-100 | | Synonyms: | ABT-100;ABT-100
(ABT100);[1,1'-Biphenyl]-3-carbonitrile, 6-[(2S)-2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1H-imidazol-5-yl)ethoxy]-4'-(trifluoromethoxy)- | | CAS: | 450839-40-4 | | MF: | C27H19F3N4O3 | | MW: | 504.46 | | EINECS: | | | Product Categories: | | | Mol File: | 450839-40-4.mol |  |
| | ABT-100 Chemical Properties |
| Boiling point | 722.0±60.0 °C(Predicted) | | density | 1.29±0.1 g/cm3(Predicted) | | storage temp. | -20°C, protect from light | | solubility | Acetonitrile: Slightly soluble: 0.1-1 mg/ml
DMSO: Sparingly soluble: 1-10 mg/ml | | form | Solid | | pka | 12.15±0.29(Predicted) | | color | White to off-white |
| | ABT-100 Usage And Synthesis |
| Uses | ABT-100 is a potent, highly selective and orally active farnesyltransferase inhibitor. ABT-100 inhibits cell proliferation (IC50s of 2.2 nM, 3.8 nM, 5.9 nM, 6.9 nM, 9.2 nM, 70 nM and 818 nM for EJ-1, DLD-1, MDA-MB-231, HCT-116, MiaPaCa-2, PC-3, and DU-145 cells, respectively), increases apoptosis and decreases angiogenesis. ABT-100 possesses broad-spectrum antitumor activity[1]. | | in vivo | ABT-100 (6.25-12.5 mg/kg/day; subcutaneous injection; daily; for 21 days; C.B-17 scid male mice) treatment regresses EJ-1 tumors in mice[1]. | Animal Model: | C.B-17 scid male mice with EJ-1 cells[1] | | Dosage: | 6.25 mg/kg/day, 12.5 mg/kg/day | | Administration: | Subcutaneous injection; daily; for 21 days | | Result: | Regressed EJ-1 tumors in C.B-17 scid male mice.
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| | References | [1] Ferguson D, et al. Antitumor activity of orally bioavailable farnesyltransferase inhibitor, ABT-100, is mediated by antiproliferative, proapoptotic, and antiangiogenic effects in xenograft models. Clin Cancer Res. 2005 Apr 15;11(8):3045-54. DOI:10.1158/1078-0432.CCR-04-2041
[2] VINICIO CARLONI Pietro P Francesco Vizzutti. Farnesyltransferase inhibitor, ABT-100, is a potent liver cancer chemopreventive agent.[J]. Clinical Cancer Research, 2005, 11 11: 4266-4274. DOI: 10.1158/1078-0432.ccr-04-2386
[3] LOREN G. FONG. A Protein Farnesyltransferase Inhibitor Ameliorates Disease in a Mouse Model of Progeria[J]. Science, 2006, 311 5767. DOI: 10.1126/science.1124875 |
| | ABT-100 Preparation Products And Raw materials |
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