DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE manufacturers
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| | DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE Basic information |
| Product Name: | DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE | | Synonyms: | PYRIMIDINE-4,6-DICARBOXYLIC ACID DIMETHYL ESTER;4,6-PyriMidinedicarboxylic acid, 4,6-diMethyl ester;DiMethyl 4,6-pyriMidinedicarboxylate;4,6-dimethyl pyrimidine-4,6-dicarboxylate;DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE;DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE ISO 9001：2015 REACH | | CAS: | 6345-43-3 | | MF: | C8H8N2O4 | | MW: | 196.16 | | EINECS: | 929-172-3 | | Product Categories: | | | Mol File: | 6345-43-3.mol |  |
| | DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE Chemical Properties |
| Melting point | 78-79°C | | Boiling point | 305.7±22.0 °C(Predicted) | | density | 1.293±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | -3.53±0.17(Predicted) | | Appearance | White to off-white Solid |
| | DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE Usage And Synthesis |
| Uses | Dimethyl 4,6-Pyrimidinedicarboxylate is a compound involved in the preparation of radiolabeled selective matrix metalloproteinase 13 (MMP-13) inhibitors. | | Synthesis | The general procedure for the synthesis of dimethyl pyrimidine-4,6-dicarboxylate from methanol and pyrimidine-4,6-dicarboxylic acid was as follows: 10 g (0.059 mol) of pyrimidine-4,6-dicarboxylic acid was suspended in 1.4 L of methanol, followed by the addition of 10.93 mL (0.356 mol) of concentrated hydrochloric acid. The reaction mixture was stirred at reflux for 3 hours at 65 °C. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and the residue was redissolved in methanol. After filtration of the mixture, the filtrate was concentrated to afford the product dimethyl pyrimidine-4,6-dicarboxylate in a yield of 11.02 g (94.4% yield). Mass spectrometry (ES+) analysis showed m/e = 197.20. | | References | [1] Patent: US2003/229103, 2003, A1. Location in patent: Page 9
[2] Journal of Medicinal Chemistry, 2008, vol. 51, # 22, p. 7053 - 7056
[3] Patent: WO2010/43866, 2010, A2. Location in patent: Page/Page column 77
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 1, p. 307 - 321 |
| | DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE Preparation Products And Raw materials |
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