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SBI-0640756

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Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:SBI-0640756
CAS:1821280-29-8
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:SBI-0640756
CAS:1821280-29-8
Purity:99.75% Package:1mg;33USD|5mg;89USD|10mg;143USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:SBI-0640756
CAS:1821280-29-8
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471;
Email: sales@sarms4muscle.com
Products Intro: Product Name:SBI-0640756
CAS:1821280-29-8
Remarks:SBI-0640756
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354;
Email: support@targetmol.com
Products Intro: Product Name:SBI-0640756；SBI-756;SBI 0640756;SBI0640756
CAS:1821280-29-8
Package:2 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY

SBI-0640756 manufacturers

  • SBI-0640756
  • SBI-0640756 pictures
  • $33.00 / 1mg
  • 2026-04-17
  • CAS:1821280-29-8
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  • Purity: 99.83%
  • Supply Ability: 10g
SBI-0640756 Basic information
Product Name:SBI-0640756
Synonyms:SBI-0640756;(E)-6-chloro-3-(3-(5-fluoropyridin-3-yl)acryloyl)-4-phenylquinolin-2(1H)-one;CS-2838;SBI 756;SBI-0640756;SBI 0640756;SBI0640756;SBI 756;SBI756;SBI-756;SBI756;SBI-756;2(1H)-Quinolinone,6-chloro-3-[(2E)-3-(5-fluoro-3-pyridinyl)-1-oxo-2-propen-1-yl]-4-phenyl-
CAS:1821280-29-8
MF:C23H14ClFN2O2
MW:0
EINECS:
Product Categories:
Mol File:Mol File
SBI-0640756 Structure
SBI-0640756 Chemical Properties
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO : ≥ 26 mg/mL (64.23 mM)
form Solid
color Light yellow to yellow
InChI1S/C23H14ClFN2O2/c24-16-7-8-19-18(11-16)21(15-4-2-1-3-5-15)22(23(29)27-19)20(28)9-6-14-10-17(25)13-26-12-14/h1-13H,(H,27,29)/b9-6+
InChIKeyVVWGPQZBDQVQRC-RMKNXTFCSA-N
SMILESFC1=CN=CC(/C=C/C(C2=C(C3=CC=CC=C3)C4=C(C=CC(Cl)=C4)NC2=O)=O)=C1
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
Hazard ClassificationsEye Irrit. 2
Skin Irrit. 2
STOT SE 3
MSDS Information
SBI-0640756 Usage And Synthesis
UsesSBI-0640756 (SBI-756) is an inhibitor of eIF4G1 and disrupts the eIF4F complex.
Biological ActivitySBI-0640756 is a potent inhibitor of eIF4G1 th at disrupts the eIF4F complex assembly independently of mTOR. SBI-0640756 potently inhibits growth of BRAF-resistant and BRAF-independent melanomas including NRAS- and NF1-mutant melanomas. SBI-0640756 exhibits low toxicity against nontransformed fibroblasts. SBI-0640756 also suppressed AKT and NF-kB signaling.
in vivo

SBI-0640756 (SBI-756) (0.5 mg/kg, i.p.) delays tumor onset and reduces tumor incidence by 50% in NrasQ61K/Ink4a–/– genetic model. SBI-0640756 (SBI-756) (1 mg/kg, 2 times per week, i.p.) in combination with BRAF inhibitor potently suppresses growth of established tumors and does not resume tumor growth in immunodeficient mice bearing A375 tumors[1].

IC 50eIF4
References[1] Feng Y et al. SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex. Cancer Res, 2015 Dec 15, 75(24):5211-8. DOI:10.1158/0008-5472.CAN-15-0885
SBI-0640756 Preparation Products And Raw materials
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