Angiogenesis Inhibitor

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Angiogenesis Inhibitor Basic information
Product Name:Angiogenesis Inhibitor
Synonyms:Angiogenesis Inhibitor;Angiogenesis Inhibitor - CAS 186611-44-9 - Calbiochem;2H-Indol-2-one, 1,3-dihydro-3-(1H-imidazol-5-ylmethylene)-
CAS:186611-44-9
MF:C12H9N3O
MW:211.22
EINECS:
Product Categories:
Mol File:186611-44-9.mol
Angiogenesis Inhibitor Structure
Angiogenesis Inhibitor Chemical Properties
Melting point 228-230 °C(Solv: ethanol (64-17-5))
Boiling point 572.7±50.0 °C(Predicted)
density 1.404±0.06 g/cm3(Predicted)
storage temp. +2C to +8C
solubility DMSO: 5mg/mL
form Yellow solid
pka11.70±0.20(Predicted)
color yellow
Safety Information
WGK Germany WGK 1
Storage Class11 - Combustible Solids
MSDS Information
Angiogenesis Inhibitor Usage And Synthesis
UsesAngiogenesis Inhibitor is a cell-permeable indolinone. Anti-angiogenic activity.
DefinitionChEBI: 3-(1H-imidazol-5-ylmethylidene)-1H-indol-2-one is a member of indoles.
General DescriptionA cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 μM in an in vitro rat aortic ring model). The potency has been reported to be comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 μM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 μM).
Biochem/physiol ActionsCell permeable: yes
Angiogenesis Inhibitor Preparation Products And Raw materials
Tag:Angiogenesis Inhibitor(186611-44-9) Related Product Information
2-Propynamide, N-[3-[(2-ethyl-4-methyl-1H-imidazol-5-yl)methylene]-2,3-dihydro-2-oxo-1H-indol-5-yl]-, hydrate (1:1) NA 2H-Indol-2-one, 1,3-dihydro-3-(2-pyridinylmethylene)-, (3Z)- SU 9516 6-Bromo-3-(3H-imidazol-4-ylmethylene)-1,3-dihydro-indol-2-one (3Z)-3-[(1H-imidazol-5-yl)methylidene]-2,3-dihydro-1H-indol-2-one