Pifithrin-α, p-nitro, cyclic
| 中文名称 | Pifithrin-α, p-nitro, cyclic |
|---|---|
| 中文同义词 | 5,6,7,8-四氢-2-(4-硝基苯基)咪唑并[2,1-b]苯并噻唑;PIFITHRIN-Α, P-NITRO, CYCLIC;化合物PIFITHRIN-Α, P-NITRO, CYCLIC;PIFITHRIN-Α (P53抑制剂);PIFITHRIN-伪, P-NITRO, CYCLIC;CYCLIC PIFITHRIN-ALPHA-P-NITRO,TRANSCRIPTIONAL P53抑制剂;化合物PIFITHRIN-Α, P-NITRO, CYCLIC,10 MM DMSO 溶液;2-(4-硝基苯基)-5,6,7,8-四氢苯并[d]咪唑并[2,1-b]噻唑 |
| 英文名称 | Pifithrin-α, p-nitro, cyclic |
| 英文同义词 | Pifithrin-α, p-nitro, cyclic;p-nitro-Cyclic Pifithrin-α;Pifithrin-alpha, p-Nitro, Cyclic;2-(4-Nitro-phenyl)-5,6,7,8-tetrahydro-benzo[d]imidazo[2,1-b]thiazole;p-nitro Cyclic Pifithrin-.alpha.;Cyclic pifithrin-α-p-nitro;Pifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem;p-Nitro-Cyclic Pifithrin-a |
| CAS号 | 60477-38-5 |
| 分子式 | C15H13N3O2S |
| 分子量 | 299.35 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 60477-38-5.mol |
| 结构式 |  |
Pifithrin-α, p-nitro, cyclic 性质
| 熔点 | 233-234 °C(Solv: N,N-dimethylformamide (68-12-2); water (7732-18-5)) |
|---|---|
| 密度 | 1.53±0.1 g/cm3(Predicted) |
| 储存条件 | -20C |
| 溶解度 | 二甲基甲酰胺中≤1mg/ml |
| 酸度系数(pKa) | 6.14±0.20(Predicted) |
| 形态 | 黄色固体 |
| 颜色 | 浅黄至黄色 |
| InChI | 1S/C15H13N3O2S/c19-18(20)11-7-5-10(6-8-11)12-9-17-13-3-1-2-4-14(13)21-15(17)16-12/h5-9H,1-4H2 |
| InChIKey | XMFNSEDROOHGBY-UHFFFAOYSA-N |
| SMILES | [s]1c2[n](c4c1CCCC4)cc(n2)c3ccc(cc3)[N+](=O)[O-] |
Pifithrin-α, p-Nitro, Cyclic (PFN-α)，是细胞通透性的 p53 抑制剂。Pifithrin-α, p-Nitro, Cyclic 对暴露于 Etoposide 的皮层神经元的保护作用比 Pifithrin-α 强一个数量级 (ED50=30 nM)。Pifithrin-α, p-Nitro, Cyclic 也作为 p53 转录后活性抑制剂。Pifithrin-α, p-Nitro, Cyclic 不阻止 p53 上的 S15 残基磷酸化。
Pifithrin-α, p-Nitro, Cyclic (PFN-α) efficiently blocks p53-triggered cell death and p21/WAF1 expression in cortical neurons exposed to etoposide at concentrations one order magnitude lower than that in PFT-α.
Intraocular injection of pifithrin-α slightly increases survival of retinal ganglion cell (RGC) at the concentration of 6 μM but not at 0.06 μM. Pifithrin-α, p-Nitro, Cyclic (PFN-α) is not effective in vivo, even at 6 μM.
Pifithrin-α, p-Nitro, Cyclic shows the half-life (t
1/2
) of 6 hours (when incubated in biological conditions).
安全信息
| WGK Germany | WGK 1 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-123076 | Pifithrin-α, p-Nitro, Cyclic | 60477-38-5 | 1 mg | 454元 |
| 2025/12/22 | HY-123076 | Pifithrin-α, p-nitro, cyclic Pifithrin-α, p-Nitro, Cyclic | 60477-38-5 | 5mg | 1000元 |