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| | XLR11 N-(4-hydroxypentyl) metabolite (CRM) Basic information |
| Product Name: | XLR11 N-(4-hydroxypentyl) metabolite (CRM) | | Synonyms: | XLR11 N-(4-hydroxypentyl) metabolite (CRM);[1-(5-fluoro-4-hydroxypentyl)indol-3-yl]-(2,2,3,3-tetramethylcyclopropyl)methanone;XLR11 N-(4-hydroxypentyl) metabolite RM;4-Hydroxypentyl XLR11;XLR-11 4-hydroxypentyl metabolite;XLR11 N-(4-hydroxypentyl) metabolite;Methanone, [1-(5-fluoro-4-hydroxypentyl)-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)- | | CAS: | 1782099-36-8 | | MF: | C21H28FNO2 | | MW: | 345.45 | | EINECS: | | | Product Categories: | | | Mol File: | 1782099-36-8.mol |  |
| | XLR11 N-(4-hydroxypentyl) metabolite (CRM) Chemical Properties |
| Boiling point | 490.0±40.0 °C(Predicted) | | density | 1.14±0.1 g/cm3(Predicted) | | pka | 13.88±0.20(Predicted) |
| | XLR11 N-(4-hydroxypentyl) metabolite (CRM) Usage And Synthesis |
| Description | XLR11 is a synthetic cannabinoid (CB) featuring a tetramethylcyclopropyl group, which reportedly confers selectivity for the peripheral CB2 receptor over the central CB1 receptor.1 XLR11 also has an N-(5-fluoropentyl) chain, which increases binding to both CB receptors.2 XLR11 N-(4-hydroxypentyl) metabolite is an expected phase I metabolite of XLR11, based on the known metabolism of similar compounds.3,4 The physiological properties of this compound have not been evaluated. This product is intended for forensic and research applications. | | Uses | 4-Hydroxypentyl XLR11 is a metabolite of XLR11 (X746300), an aminoalkylindole compound that is expected to be a cannabinoid (CB) mimetic. | | Definition | ChEBI: XLR11 N-(4-hydroxypentyl) metabolite is a member of indoles. | | References | 1. Frost, J.M., Dart, M.J., Tietje, K.R., et al. Indol-3-ylcycloalkyl ketones: Effects of N1 substituted indole side chain variations on CB2 cannabinoid receptor activity J. Med. Chem. 53(1),295-315(2010).
2. Makriyannis, A., and Deng, H. Cannabimimetic indole derivatives US7241799B2,(2001).
3. Zhang, Q., Ma, P., Cole, R.B., et al. Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MS Anal. Bioanal. Chem. 386(5),1345-1355(2006).
4. Wintermeyer, A., Mller, I., Thevis, M., et al. In vitro phase I metabolism of the synthetic cannabimimetic JWH-018 Anal. Bioanal. Chem. 398(5),2141-2153(2010). |
| | XLR11 N-(4-hydroxypentyl) metabolite (CRM) Preparation Products And Raw materials |
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