1-(2,4,5-Trihydroxyphenyl)ethanone manufacturers
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| | 1-(2,4,5-Trihydroxyphenyl)ethanone Basic information |
| Product Name: | 1-(2,4,5-Trihydroxyphenyl)ethanone | | Synonyms: | 1-(2,4,5-Trihydroxyphenyl)ethanone;acetophenone, 2,4,5-trihydroxy;Ethanone, 1-(2,4,5-trihydroxyphenyl)-;1-(2,4,5-trihydroxyphenyl)ethan-1-one | | CAS: | 1818-27-5 | | MF: | C8H8O4 | | MW: | 168.15 | | EINECS: | | | Product Categories: | | | Mol File: | 1818-27-5.mol |  |
| | 1-(2,4,5-Trihydroxyphenyl)ethanone Chemical Properties |
| Melting point | 200-202 °C | | Boiling point | 404.3±30.0 °C(Predicted) | | density | 1.446±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | pka | 7.81±0.23(Predicted) |
| | 1-(2,4,5-Trihydroxyphenyl)ethanone Usage And Synthesis |
| Preparation | Preparation by Fries rearrangement of 1,2,4-triacetoxy-benzene,
with aluminium chloride in nitrobenzene (30–43%)
with zinc chloride at 135–140° (49–53%)
with p-toluenesulfonic acid in refluxing tetrachloroethane or benzene or without solvent at 135–140° (60%). | | Synthesis | General procedure for the synthesis of 1-(2,4,5-trihydroxyphenyl)ethan-1-one from 1-(6-hydroxybenzo[D][1,3]dioxolan-5-yl)ethan-1-one: The compound 1-(6-hydroxybenzo[D][1,3]dioxolan-5-yl)ethan-1-one (4 g, 19.03 mmol) was dissolved in chlorobenzene (20 mL) at room temperature, and in a Trichlorosilane (6.6 g, 49.47 mmol) was slowly added dropwise under nitrogen protection. The reaction mixture was heated to reflux for 24 hours. Upon completion of the reaction, the chlorobenzene was removed by rotary evaporation. The residue was dissolved in 1 M hydrochloric acid (50 mL) and extracted with ethyl acetate. The extract was post-treated and purified by silica gel column chromatography to afford 1-(2,4,5-trihydroxyphenyl)ethanone (2.1 g, 12.7 mmol) as a pale yellow solid in 66.9% yield. | | References | [1] Patent: CN107935982, 2018, A. Location in patent: Paragraph 0023; 0024
[2] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 13, p. 3872 - 3875 |
| | 1-(2,4,5-Trihydroxyphenyl)ethanone Preparation Products And Raw materials |
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