- SPDP-PEG8-NHS ester
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- $0.00 / 500mg
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2025-06-07
- CAS:1252257-56-9
- Min. Order: 500mg
- Purity: >99.00%
- Supply Ability: 500mg
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| | SPDP-PEG8-NHS ester Basic information |
| Product Name: | SPDP-PEG8-NHS ester | | Synonyms: | SPDP-PEG8-NHS ester;SDPD-PEG8-NHS;SPDP-dPEG(R)8-NHS ester;Opss-peg(8)-nhs;LC-PEG8-SPDP;Propanoic acid, 3-[[25-oxo-27-(2-pyridinyldithio)-3,6,9,12,15,18,21-heptaoxa-24-azaheptacos-1-yl]oxy]-, 2,5-dioxo-1-pyrrolidinyl ester;SPDP-dPEG®;8-NHS ester | | CAS: | 1252257-56-9 | | MF: | C31H49N3O13S2 | | MW: | 735.86306 | | EINECS: | | | Product Categories: | peg | | Mol File: | 1252257-56-9.mol |  |
| | SPDP-PEG8-NHS ester Chemical Properties |
| density | 1.29±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | form | solid or viscous liquid | | pka | 15.01±0.46(Predicted) | | InChIKey | HKFFRXQWQMCBEO-UHFFFAOYSA-N | | SMILES | O=C(NCCOCCOCCOCCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)CCSSC2=NC=CC=C2 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | SPDP-PEG8-NHS ester Usage And Synthesis |
| Description | SPDP-PEG8-NHS ester is a PEG linker containing an SPDP crosslinker and an NHS ester. The SPDP crosslinker is reactive toward amine and thiol groups and contains a cleavable disulfide bond. This crosslinker is also membrane permeable which allows for intracellular reactions to take place. The NHS ester can react with primary amines to form stable amide bonds. The hydrophilic PEG linker increases the water solubility of compounds in aqueous media. | | Uses | LC-PEG8-SPDP is a cleavable ADC linker used for the antibody-drug conjugates (ADCs)[1]. | | reaction suitability | reactivity: thiol reactive
reagent type: cross-linking reagent
reactivity: amine reactive | | IC 50 | Disulfide Cleavable Linker; Cleavable Linker | | References | [1] Zhao RY, et al. Synthesis and evaluation of hydrophilic linkers for antibody-maytansinoid conjugates. J Med Chem. 2011 May 26;54(10):3606-23. DOI:10.1021/jm2002958 |
| | SPDP-PEG8-NHS ester Preparation Products And Raw materials |
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