1-(1-(3-ethoxyphenyl)propyl)-7-(pyrimidin-5-ylmethoxy)-4,5-dihydro-1H-benzo[g]indazole-3-carboxylic acid

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1-(1-(3-ethoxyphenyl)propyl)-7-(pyrimidin-5-ylmethoxy)-4,5-dihydro-1H-benzo[g]indazole-3-carboxylic acid manufacturers

  • ATZ-1993
  • ATZ-1993 pictures
  • $2180.00
  • 2026-05-11
  • CAS:219705-77-8
  • Purity:
  • Supply Ability: 10g
1-(1-(3-ethoxyphenyl)propyl)-7-(pyrimidin-5-ylmethoxy)-4,5-dihydro-1H-benzo[g]indazole-3-carboxylic acid Basic information
Product Name:1-(1-(3-ethoxyphenyl)propyl)-7-(pyrimidin-5-ylmethoxy)-4,5-dihydro-1H-benzo[g]indazole-3-carboxylic acid
Synonyms:1-(1-(3-ethoxyphenyl)propyl)-7-(pyrimidin-5-ylmethoxy)-4,5-dihydro-1H-benzo[g]indazole-3-carboxylic acid;1H-Benz[g]indazole-3-carboxylic acid, 1-[1-(3-ethoxyphenyl)propyl]-4,5-dihydro-7-(5-pyrimidinylmethoxy)-;ATZ-1993
CAS:219705-77-8
MF:C28H28N4O4
MW:484.55
EINECS:
Product Categories:
Mol File:219705-77-8.mol
1-(1-(3-ethoxyphenyl)propyl)-7-(pyrimidin-5-ylmethoxy)-4,5-dihydro-1H-benzo[g]indazole-3-carboxylic acid Structure
1-(1-(3-ethoxyphenyl)propyl)-7-(pyrimidin-5-ylmethoxy)-4,5-dihydro-1H-benzo[g]indazole-3-carboxylic acid Chemical Properties
Boiling point 725.6±60.0 °C(Predicted)
density 1.30±0.1 g/cm3(Predicted)
pka3.84±0.20(Predicted)
Safety Information
MSDS Information
1-(1-(3-ethoxyphenyl)propyl)-7-(pyrimidin-5-ylmethoxy)-4,5-dihydro-1H-benzo[g]indazole-3-carboxylic acid Usage And Synthesis
UsesATZ-1993 is an orally active, nonpeptide endothelin receptor subtype Aand endothelin receptor subtype B antagonist with pKi values of 8.69, 7.20, respectively. ATZ-1993 has the potential for the research of intimal hyperplasia after balloon denudation of the carotid artery[1].
in vivo

ATZ-1993 (30 mg/kg; drinking water, daily for 1 week) inhibits the intimal hyperplasia intimal hyperplasia after balloon denudation[1].

Animal Model:Japanese White male rabbits[1]
Dosage:30 mg/kg
Administration:Drinking water, daily for 1 weeks
Result:Inhibited the intimal hyperplasia with the inhibition rate approximately 77%, increased in intima:media ratio and DNA content.
IC 50ETA: 8.69 (pKi); ETB: 7.20 (pKi)
References[1] Azuma H, et al. ATZ1993, an orally active and novel nonpeptide antagonist for endothelin receptors and inhibition of intimal hyperplasia after balloon denudation of the rabbit carotid artery. Jpn J Pharmacol. 1999 Sep;81(1):21-8. DOI:10.1254/jjp.81.21
1-(1-(3-ethoxyphenyl)propyl)-7-(pyrimidin-5-ylmethoxy)-4,5-dihydro-1H-benzo[g]indazole-3-carboxylic acid Preparation Products And Raw materials
Tag:1-(1-(3-ethoxyphenyl)propyl)-7-(pyrimidin-5-ylmethoxy)-4,5-dihydro-1H-benzo[g]indazole-3-carboxylic acid(219705-77-8) Related Product Information
EDNRA Protein-VLP, Human (HEK293) EDNRA Protein, Human (Cell-Free, C-His) Endothelin-2 (49-69), human TFA Ednra protein, human (p.pastoris, his) Endothelin-3, human, mouse, rabbit, rat TFA