TLR2-IN-C29
| 中文名称 | TLR2-IN-C29 |
|---|---|
| 中文同义词 | 3-((2-羟基-3-甲氧基亚苄基)氨基)-2-甲基苯甲酸;化合物C29;化合物C29,10 MM DMSO 溶液;TLR2-IN-C29【CAS:363600-92-4】【规格:25mg】【纯度:98%】;TLR2-IN-C29【CAS：363600-92-4】【规格：25mg】【纯度：98%】 |
| 英文名称 | TLR2-IN-C29 |
| 英文同义词 | C29;C 29;C-29;TLR2-IN-C29;R2-IN-C29;Benzoic acid, 3-[[(2-hydroxy-3-methoxyphenyl)methylene]amino]-2-methyl-;3-((2-Hydroxy-3-methoxybenzylidene)amino)-2-methylbenzoic acid;TLR2-IN-C29 (C29 );C29,TLR2,Inhibitor,hTLR2/1,inhibit,C-29,Toll-like,Toll-like Receptor (TLR),hTLR2/6,C 29;C29, 10 mM in DMSO |
| CAS号 | 363600-92-4 |
| 分子式 | C16H15NO4 |
| 分子量 | 285.29 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 363600-92-4.mol |
| 结构式 |  |
TLR2-IN-C29 性质
| 熔点 | >192°C (dec.) |
|---|---|
| 沸点 | 505.7±50.0 °C(Predicted) |
| 密度 | 1.21±0.1 g/cm3(Predicted) |
| 储存条件 | Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | 可溶于DMSO（少许）、甲醇（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | 4.01±0.10(Predicted) |
| 颜色 | 深橙色 |
| 稳定性 | 湿气敏感 |
| InChI | InChI=1S/C16H15NO4/c1-10-12(16(19)20)6-4-7-13(10)17-9-11-5-3-8-14(21-2)15(11)18/h3-9,18H,1-2H3,(H,19,20) |
| InChIKey | WTGMGRFVBFDHGQ-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=CC(N=CC2=CC=CC(OC)=C2O)=C1C |
TLR2-IN-C29 (C29)是一种 Toll-like receptor 2 (TLR2) 的抑制剂，可抑制TLR2/1和TLR2/6的信号传导。
| Target | Value |
|
TLR2
() |
C29 (10 or 50 μΜ; 1 hour) blocks P3C- and P2C-induced IL-8 mRNA dose-dependently in HEK-TLR2 stable transfectants. C29 (50-200 μM; 1 hour) inhibits P3C- and P2C-induced IL-1β gene expression significantly at both 1 h and 4 h following stimulation in THP-1 cells.
C29 (25 or 50 μΜ; 1 hour) reduces P3C-induced but not P2C-induced TNF-α mRNA and IL-12 p40 protein significantly in primary murine macrophages.
C29 (50 μΜ; 1 hour) blocks TLR2 bacterial agonist-induced proinflammatory gene expression in HEK-TLR2 cells and murine macrophages.
Western Blot Analysis
| Cell Line: | THP-1 cells |
| Concentration: | 150 μM |
| Incubation Time: | 1 hours |
| Result: | Diminished the interaction between endogenous TLR2 and myeloid differentiation primary response gene 88 (MyD88) at 15 and 30 min poststimulation with P3C. |
Western Blot Analysis
| Cell Line: | Murine peritoneal macrophages |
| Concentration: | 50 μM |
| Incubation Time: | 1 hours |
| Result: |
Blocked robust MAPK activation at 30 min and reduced NF-κB activation from 5 to 30 min.
Prevented P3C-induced degradation of IκBα at 15 and 30 min. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/09/19 | S6597 | TLR2-IN-C29 TLR2-IN-C29 | 363600-92-4 | 5mg | 1170元 |
| 2025/09/19 | S6597 | TLR2-IN-C29 | 363600-92-4 | 10mM (1mL in DMSO) | 1285.83元 |