6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物
| 中文名称 | 6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物 |
|---|---|
| 中文同义词 | 6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物;6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物;6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物;ARL 67156 trisodium salt hydrate[A265]试剂;ARL 67156 trisodium salt hydrate[A265]试剂 |
| 英文名称 | 6-N,N-Diethyl-D-beta-gamma-dibromomethylene ATP |
| 英文同义词 | ARL 67156 trisodium salt hydrate;ARL-67156;ARL 67156 TRISODIUM;ARL 67156 TRISODIUM SALT;FPL-67156;FPL 67156 TRISODIUM;6-N,N-DIETHYL-BETA-GAMMA-DIBROMOMETHYLENE-D-ADENOSINE-5-TRIPHOSPHATE TRISODIUM;6-N,N-DIETHYL-D-B,G-DIBROMOMETHYLENEATP TRISODIUM SALT |
| CAS号 | 160928-38-1 |
| 分子式 | C15H24Br2N5O12P3 |
| 分子量 | 719.11 |
| EINECS号 | |
| 相关类别 | ATPase |
| Mol文件 | 160928-38-1.mol |
| 结构式 |  |
6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物 性质
| 沸点 | 879.6±75.0 °C(Predicted) |
|---|---|
| 密度 | 2.32±0.1 g/cm3(Predicted) |
| 储存条件 | −20°C |
| 溶解度 | 在水中的溶解度10 mg/mL |
| 形态 | 固体 |
| 酸度系数(pKa) | 0.82±0.50(Predicted) |
| 颜色 | 米白色 |
| 水溶解性 | H2O: >20mg/mL DMSO: insoluble |
| InChIKey | UWMONIJVKGTUGE-OPKBHZIBSA-K |
| SMILES | O.[Na+].[Na+].[Na+].CCN(CC)c1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)C(Br)(Br)P([O-])([O-])=O)[C@@H](O)[C@H]3O |
ARL67156 trisodium salt hydrate 是一种 ecto-ATPase 抑制剂。ARL67156 trisodium salt hydrate 是弱的竞争性 NTPDase1 (CD39)，NTPDase3 和 NPP1 抑制剂，Ki 分别为 11，18 和 12 μM。ARL67156 trisodium salt hydrate 可预防体内主动脉瓣钙化。
Ki: 11 μM (NTPDase1), 18 μM (NTPDase3), 12 μM (NPP1)
ARL67156 trisodium salt is also an effective inhibitor of UTP breakdown by superior cervical ganglion cells and to potentiate contractions elicited by this nucleotide in isolated tail artery of rat. ARL67156 is not an effective inhibitor of NTPDase2, NTPDase8, NPP3 and ecto-5′-nucleotidase (CD73), although it also reduces the activity of these enzymes.
Pre-treatment of mice with ARL67156 (2 mg/kg, i.p.), a selective inhibitor of CD39 (CD39i), completely prevents the increase of serum adenosine concentration induced by Fructose 1,6-bisphosphate (FBP; 100 mg/kg).
| Animal Model: | C57BL/6 mice |
| Dosage: | 2 mg/kg |
| Administration: | Pre-treated (i.p.) 1 h before administration of FBP (100 mg/kg) |
| Result: | Completely prevented the increase of serum adenosine concentration induced by FBP. |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-103265 | 6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物 ARL67156 trisodium salt | 160928-38-1 | 1mg | 1800元 |
| 2025/12/22 | HY-103265 | 6-N,N-二乙基-Β-Γ-二溴亚甲基-D-腺苷E-5'-三磷酸钠水合物 ARL67156 trisodium | 160928-38-1 | 5 mg | 5400元 |