- Trifluoroacetophenone
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- $0.00 / 1KG
-
2026-03-20
- CAS:434-45-7
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20 mt
- Trifluoroacetophenone
-
- $1.00 / 1KG
-
2025-12-12
- CAS:434-45-7
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 300KG
- Trifluoroacetophenone
-
- $10.00 / 1kg
-
2025-04-15
- CAS:434-45-7
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20ton
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| | Trifluoroacetophenone Basic information |
| Product Name: | Trifluoroacetophenone | | Synonyms: | α,α,α-Trifluoroacetophenone, Phenyl trifluoromethyl ketone;1-Phenyl-2,2,2-trifluoroethanone;alpha,alpha,alpha-Trifluoroacetophenone,99%;2,2,2-Trifluoro-1-phenyl-1-ethanone;2,2,2-trifluroacetophenone;NSC 42752;A,A,A-TRIFLUOROACETOPHENONE FOR SYNTHESI;1-Phenyl-2,2,2-trifluoroethan-1-one | | CAS: | 434-45-7 | | MF: | C8H5F3O | | MW: | 174.12 | | EINECS: | 207-103-1 | | Product Categories: | Aromatic Acetophenones & Derivatives (substituted);ketone;ACETYLHALIDE | | Mol File: | 434-45-7.mol |  |
| | Trifluoroacetophenone Chemical Properties |
| Melting point | -40 °C | | Boiling point | 165-166 °C (lit.)
46-48 °C/14 mmHg (lit.) | | density | 1.24 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.458(lit.) | | Fp | 107 °F | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform, Ethyl Acetate | | form | Liquid | | color | Clear colorless to yellow | | Specific Gravity | 1.240 | | Water Solubility | PRACTICALLY INSOLUBLE | | BRN | 1866286 | | InChI | 1S/C8H5F3O/c9-8(10,11)7(12)6-4-2-1-3-5-6/h1-5H | | InChIKey | KZJRKRQSDZGHEC-UHFFFAOYSA-N | | SMILES | FC(F)(F)C(=O)c1ccccc1 | | CAS DataBase Reference | 434-45-7(CAS DataBase Reference) | | NIST Chemistry Reference | Ethanone, 2,2,2-trifluoro-1-phenyl-(434-45-7) | | EPA Substance Registry System | Ethanone, 2,2,2-trifluoro-1-phenyl- (434-45-7) |
| Hazard Codes | Xi,F | | Risk Statements | 10-36/37/38 | | Safety Statements | 26-36-37/39-16 | | RIDADR | UN 1224 3/PG 3 | | WGK Germany | 3 | | Hazard Note | Corrosive/Lachrymatory | | TSCA | TSCA listed | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29147090 | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3 |
| | Trifluoroacetophenone Usage And Synthesis |
| Chemical Properties | CLEAR COLORLESS TO YELLOW LIQUID | | Uses | 2,2,2-Trifluoroacetophenone is a fluorinated acetophenone with inhibitory activity of acetylcholinesterase. 2,2,2-Trifluoroacetophenone was shown to have neuroprotective activity by inhibiting apoptosis in cerebellar granule neurons. | | General Description | 2,2,2-Trifluoroacetophenone is the starting material for the synthesis of f 3-trifluoromethyl-3-phenyldiazirine. It undergoes asymmetric reduction with optically active Grignard reagent to form 2,2,2-trifluoro-1-phenylethanol. It undergoes condensation with biphenyl, terphenyl, a mixture of biphenyl with terphenyl, phenyl ether and diphenoxybenzophenone to form new aromatic 3F polymers. | | Synthesis | 2,2,2-Trifluoroacetophenone is commonly synthesized by the following methods: (1) Trifluoroacetic acid is directly synthesized in one step by reacting directly with the Grignard reagent of bromobenzene. The yield is about 60%. The advantages of this method are simple operation and cheap raw materials. Disadvantages: exothermic and low yield. (2) in -40 , carbon disulfide solvent, the role of Lewis acid AlCl3, trifluoroacetic anhydride and the benzene ring to pay the acylation reaction preparation, yield of about 70%. Advantages of the method: one-step synthesis. Disadvantages: solvent toxicity, AlCl3 is difficult to deal with, the use of strong acid, strong alkali corrosion equipment and pollution of the environment. (3) Trifluoromethane gas and benzoate or benzoyl chloride reaction, preparation. Yield 70-80%. |
| | Trifluoroacetophenone Preparation Products And Raw materials |
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