- Marein
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- $33.00 / 1mg
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2026-01-26
- CAS:535-96-6
- Min. Order:
- Purity: 99.84%
- Supply Ability: 10g
- Marein
-
- $1.00 / 1kg
-
2019-07-06
- CAS:535-96-6
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 100KG
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| Product Name: | MAREIN | | Synonyms: | (E)-4'-(β-D-Glucopyranosyloxy)-2',3,3',4-tetrahydroxychalcone;(E)-3-(3,4-dihydroxyphenyl)-1-[4-(beta-D-glucopyranosyloxy)-2,3-dihydroxyphenyl]-2-propen-1-one;MAREIN WITH HPLC;MAREIN hplc;2',3,3',4,4'-PENTAHYDROXY-4'-GLUCOSYLCHALCONE;MAREIN;OKANIN-4'-O-GLUCOSIDE;Okaini 4’-O-β-D-glucopyranoside | | CAS: | 535-96-6 | | MF: | C21H22O11 | | MW: | 450.39 | | EINECS: | 208-623-1 | | Product Categories: | reagent;Chalcones | | Mol File: | 535-96-6.mol |  |
| | MAREIN Chemical Properties |
| Melting point | 197-202°C | | Boiling point | 835.4±65.0 °C(Predicted) | | density | 1.664±0.06 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO: soluble | | form | A crystalline solid | | pka | 6.92±0.40(Predicted) | | color | Light yellow to yellow | | InChIKey | XGEYXJDOVMEJNG-UOWIVAOKNA-N | | SMILES | [C@@H]1([C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O)OC1C=CC(C(=O)/C=C/C2C=CC(O)=C(O)C=2)=C(O)C=1O |&1:0,1,3,4,6,r| | | LogP | -0.180 (est) |
| | MAREIN Usage And Synthesis |
| Uses | Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC50 of 100 μM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects[1][2][3]. | | Definition | ChEBI: Marein is a member of flavonoids and a glycoside. | | References | [1] B Orlikova, et al. Natural chalcones as dual inhibitors of HDACs and NF-κB. Oncol Rep. 2012 Sep;28(3):797-805. DOI:10.3892/or.2012.1870
[2] Baoping Jiang, et al. Protective effects of marein on high glucose-induced glucose metabolic disorder in HepG2 cells. Phytomedicine. 2016 Aug 15;23(9):891-900. DOI:10.1016/j.phymed.2016.05.004
[3] Baoping Jiang, et al. Marein protects against methylglyoxal-induced apoptosis by activating the AMPK pathway in PC12 cells. Free Radic Res. 2016;50(11):1173-1187. DOI:10.1080/10715762.2016.1222374 |
| | MAREIN Preparation Products And Raw materials |
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