1H-Indole-5-carboxamide, 3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-2-methylbutyl)-

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1H-Indole-5-carboxamide, 3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-2-methylbutyl)- Basic information
Product Name:1H-Indole-5-carboxamide, 3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-2-methylbutyl)-
Synonyms:1H-Indole-5-carboxamide, 3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-2-methylbutyl)-;LTD4 antagonist 1;LTD4 antagonist 1,LTD-4 antagonist 1
CAS:136564-67-5
MF:C31H32F3N3O5S
MW:615.6630896
EINECS:
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Mol File:136564-67-5.mol
1H-Indole-5-carboxamide, 3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-2-methylbutyl)- Structure
1H-Indole-5-carboxamide, 3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-2-methylbutyl)- Chemical Properties
storage temp. Store at -20°C
solubility Soluble in DMSO
Safety Information
MSDS Information
1H-Indole-5-carboxamide, 3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-2-methylbutyl)- Usage And Synthesis
UsesLTD4 antagonist 1 is a potent, orally active antagonist of leukotriene D4 (LTD4) with a Ki of 0.57 nM.
in vivo

LTD4 antagonist 1 (Compound 38b) exhibits a po ED50/iv ED50 of 1.44 and 0.036 μmol/kg in LTD4-induced bronchoconstriction in guinea pigs[1].

IC 50LTD4: 0.57 nM (Ki)
References[1] Robert T. Jacobs, et al. Synthesis, Structure-Activity Relationships, and Pharmacological Evaluation of a Series of Fluorinated 3-Benzyl-5-Indolecarboxamides: Identification of 4-[[5-[((2R)-2-Methyl-4,4,4-trifluorobutyl)carbamoyl]-1-methylindol-3-yl]meth
1H-Indole-5-carboxamide, 3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-2-methylbutyl)- Preparation Products And Raw materials
Tag:1H-Indole-5-carboxamide, 3-[[2-methoxy-4-[[[(2-methylphenyl)sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-(4,4,4-trifluoro-2-methylbutyl)-(136564-67-5) Related Product Information