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BOC Sciences
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Product Name:PF-04745637
CAS:1917294-46-2
Purity:>=95% Remarks:Reach out to us for more information about custom solutions.
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1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide manufacturers
- PF-04745637
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- $40.00
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2026-07-14
- CAS:1917294-46-2
- Purity: 98.88%
- Supply Ability: 10g
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| | 1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide Basic information |
| Product Name: | 1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide | | Synonyms: | 1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide;PF-04745637;1-(4-Chlorophenyl)- N-[2-[4-hydroxy-4-(trifluoromethyl)-1-piperidinyl]-3-phenylpropyl]cyclopentanecarboxamide;PF 4745637;PF4745637;PF-4745637;PF-04746537;PF04745637,Inhibitor,bowel,TRPA1,disease,inhibit,respiratory,PF-04745637,Transient receptor potential channels,inflammatory,TRP Channel,skin | | CAS: | 1917294-46-2 | | MF: | C27H32ClF3N2O2 | | MW: | 509.0033896 | | EINECS: | | | Product Categories: | | | Mol File: | 1917294-46-2.mol |  |
| | 1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide Chemical Properties |
| Boiling point | 651.8±55.0 °C(Predicted) | | density | 1.281±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | pka | 12.14±0.20(Predicted) | | form | Solid | | color | White to off-white |
| | 1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide Usage And Synthesis |
| Uses | PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1[1]. | | Biological Activity | PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1[1].
Topically applied PF-04745637 (Compound 8; 50 mg/mL and 100 mg/mL) significantly reduces cinnamaldehyde-mediated flare in rat skin[1]. | | in vivo | Topically applied PF-04745637 (Compound 8; 50 mg/mL and 100 mg/mL) significantly reduces cinnamaldehyde-mediated flare in rat skin[1]. | | IC 50 | TRPA1: 17 nM (IC50) | | References | [1]. Laurie B. Schenkel, et al. The discovery of a potent series of carboxamide TRPA1 antagonists. J. Med. Chem. 2016, 59, 6, 2794-2809. |
| | 1-(4-chlorophenyl)-N-(2-(4-hydroxy-4-(trifluoromethyl)piperidin-1-yl)-3-phenylpropyl)cyclopentanecarboxamide Preparation Products And Raw materials |
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