- 5-CHLOROBENZOTHIOPHENE
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- $1.10 / 1g
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2025-11-18
- CAS:20532-33-6
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons
- 5-CHLOROBENZOTHIOPHENE
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- $1.00 / 1KG
-
2019-07-10
- CAS:20532-33-6
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 150KG
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| | 5-CHLOROBENZOTHIOPHENE Basic information |
| Product Name: | 5-CHLOROBENZOTHIOPHENE | | Synonyms: | 5-CHLOROBENZOTHIOPHENE;5-Chlorobenzo[b]thiophene;5-chlorine Benzothiophene;5-Chlorobenzothiophene ,98%;5-Chlorothionaphthene;6-chlorobenzo[b]thiophene;5-chloro-1-benzothiophene;5-chlorine thiofuran-2-carboxylic acid | | CAS: | 20532-33-6 | | MF: | C8H5ClS | | MW: | 168.64 | | EINECS: | | | Product Categories: | | | Mol File: | 20532-33-6.mol |  |
| | 5-CHLOROBENZOTHIOPHENE Chemical Properties |
| Boiling point | 85 °C(Press: 4 Torr) | | density | 1.349±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | Solid | | color | Off-white | | Water Solubility | Slightly soluble in water. |
| | 5-CHLOROBENZOTHIOPHENE Usage And Synthesis |
| Chemical Properties | White solid | | Uses | 5-Chlorobenzo[b]thiophene is used as pharmaceutical intermediate. | | Synthesis | To a 25 mL round-bottomed flask was added (4-chlorophenyl)(2,2-diethoxyethyl)thiane (500 mg, 1.92 mmol) and chlorobenzene (2 mL). The resulting mixture was added dropwise to a boiling solution of chlorobenzene (5 mL) in polyphosphoric acid (1 g) over 5 min. After completion of the reaction, the mixture was slowly poured into ice water (25 mL) and extracted three times with ethyl acetate (25 mL). The organic phases were combined, washed with saturated saline (50 mL) and dried over anhydrous sodium sulfate. The organic phases were concentrated under reduced pressure, and the resulting crude product was purified by silica gel column chromatography, using petroleum ether as eluent, to give 5-chlorobenzothiophene (290 mg, 90% yield) as an off-white solid. | | References | [1] Patent: US2008/21026, 2008, A1. Location in patent: Page/Page column 17; 27
[2] Patent: CN103896967, 2016, B. Location in patent: Paragraph 0048; 0052-0054
[3] Journal of Organic Chemistry, 1995, vol. 60, # 7, p. 1936 - 1938
[4] Phosphorus, Sulfur and Silicon and the Related Elements, 1994, vol. 96, # 1-4, p. 441 - 444
[5] Bioorganic and medicinal chemistry, 2004, vol. 12, # 9, p. 2251 - 2273 |
| | 5-CHLOROBENZOTHIOPHENE Preparation Products And Raw materials |
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