SCH-351591 manufacturers
- SCH-351591
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- $2500.00
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2026-05-21
- CAS:444659-43-2
- Purity:
- Supply Ability: 10g
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| | SCH-351591 Basic information |
| Product Name: | SCH-351591 | | Synonyms: | SCH-351591;D 4396;D4396;D-4396;5-Quinolinecarboxamide, N-(3,5-dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)- | | CAS: | 444659-43-2 | | MF: | C17H10Cl2F3N3O3 | | MW: | 432.18 | | EINECS: | | | Product Categories: | | | Mol File: | 444659-43-2.mol |  |
| | SCH-351591 Chemical Properties |
| Boiling point | 530.8±50.0 °C(Predicted) | | density | 1.57±0.1 g/cm3(Predicted) | | pka | 8.17±0.70(Predicted) |
| | SCH-351591 Usage And Synthesis |
| Uses | SCH 351591 is a potent, selective and orally active phosphodiesterase-4 (PDE4) inhibitor with an IC50 of 58 nM. SCH 351591 can inhibit all 4 PDE4 subtypes (A, B, C, and D). SCH 351591 has the potential for the asthma and chronic obstructive pulmonary disease (COPD) research[1]. | | Definition | ChEBI: SCH-351591 is an aromatic amide resulting from the formal condensation of the carboxy group of 8-methoxy-2-(trifluoromethyl)quinoline-5-carboxylic acid with the primary amino group of 3,5-dichloropyridin-4-amine 1-oxide. It is a potent inhibitor of phosphodiesterase IV (PDE4). It has a role as a phosphodiesterase IV inhibitor. It is a member of pyridine N-oxides, a chloropyridine, a monocarboxylic acid amide, a member of quinolines, an aromatic ether, an aromatic amide and an organofluorine compound. | | IC 50 | PDE4: 58 nM (IC50) | | References | [1] Patricia E Losco, et al. The toxicity of SCH 351591, a novel phosphodiesterase-4 inhibitor, in Cynomolgus monkeys. Toxicol Pathol. 2004 May-Jun;32(3):295-308. DOI:10.1080/01926230490431493 |
| | SCH-351591 Preparation Products And Raw materials |
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