| Company Name: |
Artis Biotech Co. Ltd.
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| Tel: |
028-67271278 18582380095 |
| Email: |
sales@artisbio.com |
| Products Intro: |
Product Name:Ethosuximide-d5
CAS:1989660-59-4
Purity:99% HPLC Package:1mg 5mg 10mg 50mg 100mg
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| Company Name: |
Nanjing Haolv Biotechnology Co.,Ltd
|
| Tel: |
025-84622273 17361806303 |
| Email: |
kexin.zhou@haolvbiotech.com |
| Products Intro: |
Product Name:Ethosuximide D5
Remarks:H-16399
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Ethosuximide D5 manufacturers
- Ethosuximide-d5
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- $393.00 / 1mg
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2025-07-19
- CAS:1989660-59-4
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Ethosuximide D5 Basic information |
| | Ethosuximide D5 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Methanol: soluble | | form | A solid |
| | Ethosuximide D5 Usage And Synthesis |
| Uses | Ethosuximide-d5 is deuterium labeled Ethosuximide. Ethosuximide, a widely prescribed anti-epileptic agent, improves the phenotypes of multiple neurodegenerative disease models and blocks the low voltage activated T-type calcium channel. | | Biological Activity | Ethosuximide-d5 is intended for use as an internal standard for the quantification of ethosuximide by GC- or LC-MS. Ethosuximide is an anticonvulsant.1,2,3,4,5 It increases glucose, fructose-1,6-bisphosphate, and pyruvate levels in rat brain when administered at a dose of 200 mg/kg.1 Ethosuximide (400 mg/kg) reduces the severity of audiogenic seizures in a rat model of barbiturate withdrawal-induced convulsions.2 It also inhibits tonic hindlimb extension induced by pentylenetetrazole or brainstem stimulation (ED50s = 35 and 70 mg/kg, respectively), as well as leptazol-induced clonic seizures (ED50 = 230 mg/kg), in rats.3,4 Ethosuximide reduces resting tremor by 60% in a macaque model of Parkinson's disease induced by MPTP when administered at a dose of 150 mg/animal for 5 days.5 Formulations containing ethosuximide have been used in the treatment of petit mal seizures. | | References | 1.Nahorski, S.R.Biochemical effects of the anticonvulsants trimethadione, ethosuximide and chlordiazepoxide in rat brainJ. Neurochem.19(8)1937-1946(1972)
2.Norton, P.R.The effects of drugs on barbiturate withdrawal convulsions in the ratJ. Pharm. Pharmacol.22(10)763-766(1970)
3.Consroe, P.F., and Wolkin, A.L.Anticonvulsant interaction of cannabidiol and ethosuximide in ratsJ. Pharm. Pharmacol.29(8)500-501(1977)
4.Chiu, P., and Burnham, W.M.The effect of anticonvulsant drugs on convulsions triggered by direct stimulation of the brainstemNeuropharmacology21(4)355-359(1982)
5.Gomez-Mancilla, B., Latulippe, J.F., Boucher, R., et al.Effect of ethosuximide on rest tremor in the MPTP monkey modelMov. Disord.7(2)137-141(1992) |
| | Ethosuximide D5 Preparation Products And Raw materials |
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