- Naphazoline nitrate
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- $0.00 / 1Kg/Bag
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2026-02-27
- CAS:5144-52-5
- Min. Order: 1KG
- Purity: 99%-101% By Titrimetry; BP
- Supply Ability: 500kg
- Naphazoline nitrate
-
- $10.00 / 1KG
-
2026-01-30
- CAS:5144-52-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
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| | Naphazoline nitrate Basic information |
| Product Name: | Naphazoline nitrate | | Synonyms: | NAPHAZOLINE NITRATE;NAPHAZOLINE NITRATE SALT;NAPHAZOLINI NITRAS;LABOTEST-BB LT00134653;2-(1-NAPHTHYLMETHYL)IMIDAZOLINIUM NITRATE;2-(1-NAPHTHYLMETHYL)IMIDAZOLINE NITRATE;2-[1-NAPHTHYLMETHYL]IMIDAZOLINE NITRATE SALT;2-(1-NAPHTHYLMETHYL)-2-IMIDAZOLINE NITRATE | | CAS: | 5144-52-5 | | MF: | C14H15N3O3 | | MW: | 273.29 | | EINECS: | 225-915-4 | | Product Categories: | API | | Mol File: | 5144-52-5.mol |  |
| | Naphazoline nitrate Chemical Properties |
| Melting point | 167-170 °C | | storage temp. | 2-8°C | | solubility | Sparingly soluble in water, soluble in ethanol (96 per cent). | | form | Solid | | color | White to off-white | | Sensitive | Hygroscopic | | BRN | 3779329 | | Major Application | pharmaceutical (small molecule) | | InChI | InChI=1S/C14H14N2.HNO3/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;2-1(3)4/h1-7H,8-10H2,(H,15,16);(H,2,3,4) | | InChIKey | ZAHXYMFVNNUHCP-UHFFFAOYSA-N | | SMILES | C12C(C=CC=C1)=CC=CC=2CC1=NCCN1.[N+]([O-])(=O)O | | CAS DataBase Reference | 5144-52-5(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 22-36/37-60-36 | | RIDADR | 3249 | | WGK Germany | 3 | | RTECS | NJ4376000 | | F | 3-10 | | HazardClass | 6.1(b) | | PackingGroup | III | | HS Code | 29332900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | Naphazoline nitrate Usage And Synthesis |
| Chemical Properties | White or almost white, crystalline powder. | | Uses | antihistamine | | Indications | Naphazoline hydrochloride and naphazoline nitrate are white or almost white crystalline powders soluble 1 in 6 and 1 in 36 water, respectively. These are potent sympathomimetic vasoconstrictors with a direct alpha-adrenergic receptor stimulatory action, and may be used as topical decongestants in 0.05% or 0.1% eyedrops. Frequent application of these solutions will produce a reactive hyperaemia. Instillation should not be repeated in less than 4-6 hours to avoid this rebound congestion.
Naphazoline eyedrops cause slight mydriasis and are contra-indicated in patients with actual or suspected closed-angle glaucoma.
Although not administered systemically, topical application of naphazoline has resulted in systemic absorption, and it is readily absorbed from the gastro-intestinal tract (Martindale, 1977). | | Definition | ChEBI: Naphazoline nitrate is a member of naphthalenes. | | in vivo | Naphazoline nitrate (0.2 mg/kg, 10 μl per eye; IP, once) reduces histamine or antigen-induced conjunctival vascular hyperpermeability in mice, and reduces conjunctivitis in mice via effects on inflammation, NGF and VEGF[1]. | Animal Model: | Female wild-type BALB/c mice (4-5 weeks, 18 ± 2 g, n=8/group, allergic conjunctivitis mouse model established using histamine or an antigen (ovalbumin))[1] | | Dosage: | 0.2 mg/mL, 10 μl per eye | | Administration: | Intraperitoneal injection (IP), once | | Result: | Significantly suppressed conjunctival dye leakage in mice with histamine or antigeninduced conjunctival vascular hyperpermeability. Reduced inflammatory reactions and the levels of IL-1β, IL-6, IFN-γ, and IL-4. Reduced the levels of IgE, GMCSF, NGF and VEGF in antigen-induced conjunctival vascular hyperpermeability mice. |
| | IC 50 | IL-1β; IL-6; IL-4 |
| | Naphazoline nitrate Preparation Products And Raw materials |
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